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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The work describes an epidemic infection by Methicillin-Resistant S. aureus in a N.I.C.U. which took place during the first six months of 1986. Hospital systemic infection supported by M.R.S.A. are frequently noticed in N.I.C.U. This is related, on the one side with a selection of antibiotic resistant bacterial strains inside the hospital premises and, on the other side with increased survival of high infectious risk neonates who are subjected to invasive medical manoeuvres. The cases reported include 7 neonates (5 of which were preterms) who were affected by a severe sepsis. From an epidemiological study it appeared that M.R.S.A. strain was introduced in N.I.C.U. by a neonate coming from the surgery after being operated for a diaphragmatic hernia. The isolation and the treatment of the carriers, the severe asepsis and the systematic disinfection of the Unit made it possible to eradicate the infectious strain. The infected neonates have been treated with an aimed antibiotic therapy, especially with Vancomycin, administration of blood and/or fresh plasma and/or immunoglobulins and/or concentrated granulocytes. The outcome was favourable for 3 neonates; of the others, 1 showed post-infectious neurological sequelae and 3 died (they were however affected by other severe associated diseases).
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PMID:[Epidemics of Staphylococcus aureus in a neonatal care unit]. 360 18

Methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly common cause of postoperative surgical site infections (SSIs). It is unclear, however, whether asymptomatic colonization or nosocomial acquisition of MRSA results in postoperative SSI. We conducted a retrospective review of patients screened for MRSA between May 2008 and October 2010 at our institution. End points included rates of MRSA infection, SSI, and the cost of routine MRSA screening of patients undergoing elective surgery. Of the 1039 patients screened preoperatively, 48 (4.6%) tested positive for MRSA by nasal or oral swab, whereas 991 (95.4%) tested negative. Forty-five (93.8%) MRSA-positive patients received vancomycin or linezolid and three (6.25%) received cefazolin perioperatively. Three (6.25%) MRSA-positive patients developed postoperative SSIs. Two required rehospitalization for intravenous antimicrobials, whereas a third patient required removal of infected abdominal mesh. Twenty (2.02%) MRSA-negative patients and four (5.26%) unscreened patients developed non-MRSA SSIs. Regardless of MRSA status, none of 609 patients who had a laparoscopic procedure or inguinal hernia repair developed SSI. Twenty-two patients needed to be screened to obtain one positive test. The role of MRSA screening and longer perioperative coverage for MRSA-positive patients undergoing complex elective procedures remains to be determined.
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PMID:Prevalence of methicillin-resistant Staphylococcus aureus in elective surgical patients at a public teaching hospital: an analysis of 1039 patients. 2302 49

Biologic prosthetics are increasingly used for the repair of abdominal wall hernia defects but can become infected as a result of peri- or early post-operative bacterial contamination. Data evaluating biofilm formation on biologic prosthetics is lacking. The aim of this study was to investigate the influence of different biologic prosthetics on the growth behavior of two different bacterial species and their ability to form biofilms. Methicillin resistant Staphylococcus aureus (MRSA) or Pseudomrnonas aeruginosa were incubated on disks of two biologic prosthetics-human acellular dermis (ADM), and porcine small intestinal submucosa (SIS). The bacteria were allowed to attach to the prosthetics and propagate into mature biofilms for 24 hours at 370C. Images of biofilms were obtained using confocal microscopy and scanning electron microscopy (SEM). The number of viable cells and the biofilm biomass were quantified by colony forming units (CFUs) and crystal violet staining respectively. Analysis of variance was performed to compare the mean values for the different prosthetics. Each biologic matrix had a distinct surface characteristic. SEM visualized mature biofilms characterized by highly organized multi-cellular structures on surface of both biologic prosthetics. Quantification of bacterial growth over time showed that ADM had the lowest CFUs and biofilm biomass at 24 hours post-inoculation compared to SIS for both bacterial strains. MRSA and P. aeruginosa can form mature biofilms on biologic prosthetics but the relative abundance of the biofilm varies on different prosthetic constructs. Biologic material composition and manufacturing methods may influence bacterial adherence.
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PMID:In vitro study of biofilm growth on biologic prosthetics. 2580 60