Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The teratogenic potential of the fungicide dinocap was evaluated in CD-1 mice. Pregnant mice were dosed by intubation with dinocap in corn oil on gestation days 7-16. Doses used were 0, 5, 10, 20, 40, 80, and 120 mg/kg/day, based on day 6 weight. Dams were killed on day 18, at which time fetuses were counted, weighed, and preserved for necropsy or skeletal examination. The highest dose killed 80% of the dams dosed, while 29% of the dams in the 80 mg/kg group died during dosing. There was no dose-related maternal mortality at lower doses. Net maternal weight gain was affected only at 80 mg/kg/day. There were no live fetuses at 120 mg/kg/day. The number of live fetuses per litter was decreased and resorptions increased at 80 mg/kg. Dose-related decreases in gravid uterus weight and fetal weight were significant at all doses of dinocap. Cleft palate was found in fetuses at 5(1/234; 0.4%), 20(46/195; 23.6%), 40(140/185; 75.5%), and 80(63/85; 74.1%) mg/kg/day. There was a dose-related increase in supernumerary ribs and a low frequency of exencephaly and umbilical hernia at high doses. This study shows that dinocap is teratogenic in the CD-1 mouse at doses well below those causing maternal toxicity.
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PMID:Teratogenic effects of the fungicide dinocap in the mouse. 287 3

Previous studies have indicated that ethylene glycol (EG) is a developmental toxicant in rats and mice primarily when ingested. This study was designed to establish no-observed-effect levels (NOELs) for developmental toxicity of EG administered by gavage in both rodent species. Dams were administered EG on Gestation Days 6-15; rats were given 0, 150, 500, 1000, or 2500 mg EG/kg/day; mice were dosed with 0, 50, 150, 500, or 1500 mg EG/kg/day. In rat dams given 2500 mg EG/kg/day, water consumption was increased during treatment and body weights were reduced throughout gestation; liver and kidney weights were increased at euthanization (Gestation Day 21). Relative liver weights were also increased at 1000 mg/kg/day. Effects observed in rat fetuses at 2500 mg/kg/day included the following: hydrocephaly; gastroschisis; umbilical hernia; fused, duplicated, or missing arches, centra, and ribs; poor ossification in thoracic and lumbar regions; and reduced body weights. Reduced body weights, duplicated or missing ribs, centra, and arches, and poor ossification were also observed in rat fetuses at 1000 mg/kg/day. In mice, there was no apparent treatment-related maternal toxicity. In mouse fetuses (Gestation Day 18), effects were observed at 1500 mg/kg/day and included reduced body weights, fused ribs and arches, poor ossification in thoracic and lumbar centra, and increased occurrence of an extra 14th rib. At 500 mg/kg/day, slight reductions in fetal body weight and increased incidences of extra ribs were observed. Under conditions of these studies, NOELs for developmental toxicity were 500 mg/kg/day for rats and 150 mg/kg/day for mice, indicating that mice were more susceptible than rats to the teratogenic effects of EG.
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PMID:Determination of a no-observed-effect level for developmental toxicity of ethylene glycol administered by gavage to CD rats and CD-1 mice. 758 22

We investigated the age-related changes in reproductive function in female rats of the Crl:CD(SD) strain. The estrous cycles were monitored from 6 to 42 weeks of age. Other females were mated with males at 6, 8, 10, 15, 19, 23, 27, 31, 35 and 40 weeks of age and caesarean section was performed on day 20 of gestation to examine their fetuses, and then reproductive parameters were calculated and fetal growth was observed. The percentage of rats exhibiting irregular estrous cycles increased from 23 weeks of age. The copulatory and fertility indices decreased from 35 and 27 weeks of age, respectively. Dams at 6 weeks of age showed low numbers of corpora lutea and implantation sites. Although the number of corpora lutea was not affected by advanced maternal age, number of implantation sites decreased from 27 weeks of age. The pre- and post-implantation loss rates increased from 23 and 31 weeks of age, respectively, and the number of live fetuses decreased from 27 weeks of age. Fetal growth retardation was observed in maternal rats older than 31 weeks of age. The external observations on the fetuses revealed umbilical hernia at 35 to 40 weeks of age. These data indicated that maternal aging affected reproductive function and fetal development from 23 and 31 weeks of age, respectively. It was considered that the appropriate age of Crl:CD(SD) female rats for the assessment of reproductive toxicity were 8 to 22 weeks.
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PMID:Maternal age and reproductive function in female Sprague-Dawley rats. 2268 2