Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During investigations of biological activity of proteolysis inhibitors from Ascaris lumbricoides, teratogenic action of alfa-chymotrypsin inhibitor (ICH) was evaluated. The inhibitor was obtained by a method of Roli and Pudles and was applied parenterally at 8-12 day of pregnancy to BALB/c mice in doses of 20-80 mg/kg of mice per 24 hours. Control groups received respectively 1 cm3 of 0.9% NaCl or 80 mg of bovine albumin. Normal status of development of internal organs in 19-days old fetuses was evaluated by a method of Wilson and Dyban and of their skeletons according to Dawson. It was found that character and exacerbation of prenatal disturbances of mice development is conditioned by the ICH dose. Teratogenic action of ICH was apparent in fetuses after application to mice of 60 and 80 mg. Most frequent developmental defects were: cleft palate, brain hernia, fusion of ribs and curvature of spine. No defects were noted in control groups. Lower doses of ICH exhibited only embryotoxic effect.
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PMID:[Teratogenic action of alpha-chymotrypsin inhibitor of Ascaris lumbricoides in mice]. 818 18

It has been found that trypsin and alpha-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn chicken embryos. Mortality rate for the chicken embryos on day 15 of incubation was 45.0 +/- 3.5% after injection of trypsin inhibitor and 44.0 +/- 3.5% after adminstration alpha-chymotrypsin inhibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administration of alpha-chymotrypsin inhibitor. The most commonly occurring abnormality was schistocelia (21.4 +/- 3.88%). Growth malformations were not found in the control groups. The trypsin and alpha-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
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PMID:Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum. 1688 3