Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An unusual foreign body reaction to silica (quartz), resembling fibrous histiocytoma, is described in 7 patients (age range 22 to 71 years). These lesions occurred in the inguinal region (4 cases) or the abdominal wall (3 cases), and in 5 instances were associated with a history of injection at the same site 10 to 41 years previously. Most commonly the injection consisted of the administration of a sclerosing agent for the repair of a hernia. Microscopically these lesions contained broad sheets of histiocytes separated by bands or concentrically lamellated nodules of collagen. Intra- and extra-cellular birefringent crystals, identified by x-ray diffraction as silica (quartz), were present in all cases and served to distinguish this process from a true neoplasm. Although the injection therapy for hernia is now obsolete, it was formerly practiced in the United States with a variety of sclerosing agents including silica (quartz). Since these lesions are often confused with a benign or malignant fibrous histiocytoma it is recommended that fibro-histiocytic lesions associated with a previous hernia or injection at the same site be examined for the presence of silica.
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PMID:Silica reaction simulating fibrous histiocytoma. 21 95

A 74-year-old man with a right inguinal hernia since 15 years was admitted because of inguinal pain and enlarged ipsilateral testis. Surgical exploration revealed a hernia with an empty hernial sac and three tumoral masses in the spermatic cord. Tumoral masses, spermatic cord, and testis were removed. Histological examination of the tumoral masses revealed a malignant inflammatory fibrous histiocytoma. The tumor infiltrated the vas deferens, pampiniform plexus, and adjacent adipose tissue. Epididymis and testis were not infiltrated. Three years after treatment with radiotherapy no recurrence or metastases have been observed.
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PMID:Inflammatory malignant fibrous histiocytoma of the spermatic cord. 284 20