Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have previously demonstrated that the increased expression of angiogenin (ANG) in pancreatic cancer is related to cancer aggressiveness; however, the relationship between ANG expression and its clinical relevance in colorectal cancer has not been demonstrated. We therefore investigated the correlation between serum ANG (sANG) concentration and colorectal cancer progression or the changes in sANG concentrations before and after cancer resection. To determination sANG concentration by ELISA, sera were obtained from colorectal cancer patients (the cancer group) preoperatively (n = 34) and postoperatively (n = 25), from hernia patients (the nonneoplastic group) preoperatively (n = 9) and postoperatively (n = 4), and from 23 healthy volunteers. The amount of ANG in the colorectal cancer tissues (n = 19) was determined by the same method. Before surgery, the mean sANG concentration in the cancer group (411.8 +/- 106.3 ng/ml) was significantly higher than that in both the nonneoplastic group (344.0 +/- 60.7 ng/ml; P = 0.04) and in the healthy volunteers (321.7 +/- 59.7 ng/ml; P = 0.0001). The degree of elevation of sANG concentration in the cancer group was more significant in the more progressed subgroups as compared with that in the normal group (versus T(is) + T1 + T2 cancer, P = 0.01; versus T3 + T4 cancer, P = 0.002; versus stage 0 + I cancer, P = 0.02; versus >stage III cancer, P = 0.001; versus Dukes' A cancer, P = 0.02; versus Dukes' C cancer, P = 0.006). After cancer resection, the mean sANG concentrations in each subgroup decreased to the same levels as those of the normal group; the degrees of reduction were more significant in the more progressed subgroups. The tissue ANG amount correlated significantly with sANG concentration (P = 0.007). These results suggest that the increased concentration of sANG that is derived from colorectal cancer correlates with cancer progression.
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PMID:Increased serum angiogenin concentration in colorectal cancer is correlated with cancer progression. 1058 92

Bochdalek hernia is a congenital defect of the lateral posterior or vertebral lumbar region on the left side of diaphragm, caused by a foramen on it, through which viscera displaced from abdomen to pleural cavity. This is a pathology frequently observed in just born babies but rarely found in teenagers or adults. In world medical history only 100 cases in adults have been reported. We present a case of a 16 years old male patient with moderate mental retard who suddenly suffered from convulsions; this was the second time it happened, because the first time (3 months ago) he showed the same clinical picture but with no further complications. Anticonvulsives were administered to the patient in the general hospital E.R., but immediately after that, he had uncontrollable and frequent nausea, vomits and regurgitation when eating. He also showed anxiety, desperation and even aggressiveness. He was also very thirsty. Three days later the patient was transferred to the gastroenterology unit where we observed the symptoms above mentioned. He also presented sialorrhea. After many difficulties to find the diagnosis due to the patient's problems to communicate even with his relatives help, we decided to perform a surgery. Endoscopy showed total occlusion of the gastric-esophagus connection and an abdomen and thorax X-r showed an abnormal image with hydro aerial level in nearly all left hemithorax. The surgical findings showed total displacement of stomach, spleen, part of the small intestine, ascending colon, cecum, appendix and proximal part of transverse colon to the left hemithorax. Surgical corrections were performed. The clinical case resolved satisfactorily. The late age of the patient, type and treatment are discussed.
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PMID:[Bochdalek's hernia in a mentally retarded adolescent]. 1771 98