Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gallium 67 citrate scanning has recently been introduced in the detection and localization of neoplastic and inflammatory processes. It has proved to be accurate when used properly, but occasionally problems in interpretation of the scans may occur due to false-positive or false-negative results. The unexpected accumulation of the radionuclide within a large benign umbilical hernia from a patient with endometrial adenocarcinoma in situ is presented. Careful clinical evaluation and the need of complementary diagnostic acids when unusual accumulations of gallium 67 citrate are found, especially in areas that could represent intestines, is emphasized.
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PMID:Unexpected gallium 67 citrate accumulation in a hernia. 743 23

The umbilical metastatic lesions have been termed the "Sister Joseph nodule" by Sir Hamilton Bailey in 1949. SJN is an important diagnostic finding, as it often is the first clue and sometimes the only physical indication of an advanced intra-abdominal malignancy. SJN is most often associated with malignancy of the stomach or ovary. It usually appears late in the course of neoplastic disease and suggests a poor prognosis. In our review of English language medical literature we could find only 27 reports of SJN in endometrial adenocarcinoma. We offer a case of SJN, presenting as umbilical hernia, in a female patient, who, 12 years previously, had undergone laparotomy with total hysterectomy and bilateral salpingo-oophorectomy for endometrial adenocarcinoma. Three years after the surgical excision of the umbilical lesion, the patient underwent surgery for a tumor located subcutaneously in the suprapubic area. Histologically, in the samples obtained with both surgical interventions, endometrioid adenocarcinoma with squamous differentiation was found. The clinical examination and imaging studies found no evidence of other metastases. On the basis of clinico-pathological analysis we offer a hypothesis about development of metastases and discuss their prognostic significance.
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PMID:[Umbilical metastasis - "Sister Joseph's nodule" of an endometrial adenocarcinoma: a case report and review of the literature]. 1180 69