Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antithrombin III concentrations were measured in 305 patients before and at intervals after operation for up to 12 days. The blood concentrations fell significantly after both major and minor surgery, but there was no relation between the expected degree of surgical trauma or the amount of blood transfused and the fall in concentration of antithrombin III. Some surgical procedures such as cholecystectomy, laparotomy, hernia repair, highly selective vagotomy, and transurethral resection of the prostate were associated with a greater depletion of antithrombin III than were other common operations and it is suggested that there are factors related to the actual site of the operation which affect the concentration of circulating antithrombin III in the postsurgical period.
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PMID:Relation between postoperative antithrombin III concentrations and site of operation. 725 2

In 25 patients with atherosclerosis of lower limb arteries (ALLA) in whom vascular operation was performed, the level of thrombin-antithrombin III (TAT) complexes and antithrombin III (AT III) activity were determined in comprehensive studies of the blood clotting system. The comparative group for the assessment of operation effect on primarily not disturbed haemostasis in humans included 10 men operated on for inguinal hernia, while the control group consisted of 54 healthy people. Blood for the determinations was taken before the operation, on the day of the operation (0-30 minutes after the operation), on the first day after it, and also on the third day in patients with hernia, and on the 7th day in patients with ALLA. In the patients with ALLA, blood hypercoagulation features were found, expressed as increased level of TAT complexes in spite of lack of abnormalities in comprehensive coagulation studies, while in the patients with hernia only increased AT III activity was found. The surgical operation caused in the patients with ALLA enhancing of hypercoagulation which was evidenced by over threefold increase of TAT complexes on the day of the operation.
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PMID:[Effect of vascular surgery on values of thrombin-antithrombin III complexes in patients with atherosclerosis of lower limb arteries]. 770 52