Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective evaluation of the relationship between Helicobacter pylori infection and gastro-oesophageal reflux disease (GORD), 93 consecutive patients (47 female: 46 male: mean age, 46 years: range 13-93) with symptoms and endoscopic evidence of GORD were studied. A total of 50 patients (54%) were H. pylori-positive on gastric antral biopsies. No significant correlation was detected between H. pylori status and grade of oesophagitis. The prevalence of H. pylori infection showed a gradual increase with age. Of 64 patients with a hiatal hernia, 28 (44%) had histological evidence of H. pylori infection of the hernia mucosa; 27 of these patients (96%) had associated H. pylori in the gastric antrum. Of the 36 patients whose hiatal hernia was H. pylori-negative, only 6 (17%) had antral H. pylori (P < 0.001). Of the 8 patients found to have Barrett's oesophagus, only 1 had H. pylori detected on the Barrett's mucosa. Our results do not support the presence of a significant association between H. pylori infection and GORD.
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PMID:Helicobacter pylori and gastro-oesophageal reflux disease--a prospective study. 800 62

Reflux esophagitis is more frequent in developed countries, and its prevalence increased in Japan in these 1/4 centuries. These increase might be based on the increase in the population of the elderly, advances in endoscopic technology, increase in the interest on esophagitis, and declined prevalence of Helicobacter pylori infection. Main pathogenesis on the reflux esophagitis are classified as 2 components. One is the motility factor of the stomach and the esophagus. Distention of the stomach causes transient LES relaxation(TLESR), leading acid reflux into the esophagus. Delayed gastric emptying enhances gastric distention, causing TLESR. Resting LES pressure might be lower than normal. Hiatal hernia is also an exaggerating factor, causing repeated reflux from the hernia sac. The other main cause is the intact acid secretion causing enough to injure the esophageal mucosa. Gastric atrophy due to Helicobacter pylori infection would be protective factor for reflux esophagitis.
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PMID:[Pathophysiology of reflux esophagitis]. 1100 3