Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen newborns with congenital cystic adenomatoid malformation and six with congenital lobar emphysema were operated on between 1970 en 1988. Eighteen children had more or less severe dyspnoea and (or) tachypnoea, one child presented with respiratory tract infection. The diagnosis could be made on the chest X-ray in most instances. However, diagnostic problems arose in the differentiation between congenital cystic adenomatoid malformation and congenital diaphragmatic hernia. Four times a laparotomy was done for presumed diaphragmatic hernia followed by thoracic surgery in the same session. In two children barium contrast studies of the gastrointestinal tract were done to exclude diaphragmatic hernia. Treatment consisted of lobectomy in 15 cases and segmental resection in four. Histological examination confirmed the clinical diagnosis in all instances. The results of the operations were excellent in all patients. No short- or long-term complications occurred.
 ...
PMID:[Lung operations in dyspneic newborn infants]. 281 85

The clinical and pathologic-anatomical picture of this rare lung malformation is described with reference to three cases from three different paediatric surgical hospitals. Methods of differential diagnosis against lung sequestration, pulmonary cysts, lobar emphysema, diaphragmatic hernia and pneumothorax are indicated. A definitive diagnosis and classification can be made only by means of histomorphological examinations.
 ...
PMID:Congenital cystic adenomatoid malformation of the lung. 310 67

Currently two genetic pulmonary disorders can be diagnosed before birth: alpha-1-antitrypsin deficiency and mucoviscidosis. For the latter there are two possible diagnostic techniques: first a study of the intestinal enzymes of the amniotic fluid, a reliable method only at the 18th week, and also a study of DNA markers (ADN) of the trophoblastic cells using molecular biological techniques: this can be performed from the 10th to 11th week of pregnancy but presupposes a family study in which there is already a subject suffering from the disorder. Foetal echocardiography enables various pulmonary abnormalities to be detected: pleural effusion, cyst, pulmonary hypoplasia and other disorders. This technique however has some limits, at least at present. Most often these severe malformations are revealed at birth such as respiratory distress or stillbirth. Adenomatous cystic malformations or congenital lobar emphysema, a posterior diaphragmatic hernia, and oesophageal atresia with oesophagotracheal fistula are the most frequent and are curable surgically.
 ...
PMID:[Prenatal diagnosis and genetic diseases of the lung]. 326 Oct 24

Three infants were studied by echo planar imaging after repair of congenital diaphragmatic hernias. Total lung volume and individual lung volumes were estimated using echo planar imaging. In the two patients with left sided hernias, the right lung was more than twice as large as the left. The patient with a right sided hernia had developed emphysema on the right side, and the right lung was twice as large as the left when estimated by echo planar imaging. Echo planar imaging studies took less than five minutes to perform and no sedation was required.
 ...
PMID:Evaluation of infants by echo planar imaging after repair of diaphragmatic hernia. 334 66

A left diaphragmatic hernia was created surgically in 20 fetal lambs between 93 and 110 days of gestation. Ten animals were alive with defects at cesarean section near term (135 to 140 days). These animals and two controls were submitted to various transpulmonary pressure gradients (inspiratory pressure minus pleural pressure). Hemodynamic and ventilatory studies were performed after the correction of the hernia. Morphometric analysis of the lung was carried out in all cases. The results showed a highly significant linear correlation between the transpulmonary pressure gradient employed and the pulmonary interstitial emphysema found at morphometry. Our data suggest that using low ventilatory pressures and not draining the pleural cavity results in less trauma to both lungs and may prevent one of the components of the pulmonary hypertension so often seen in newborns with congenital diaphragmatic hernia.
 ...
PMID:Pulmonary barotrauma in congenital diaphragmatic hernia: experimental study in lambs. 357 87

The mortality rate from congenital diaphragmatic hernia is not much better than it was 25 years ago. Most children, who are more than 24 hours of age at operation, survive. On the first day of life postoperative mortality is about 47%. Pediatric surgical problems are stabilization of the diaphragm and abdominal decompression. Some risk patients may be brought out of the fatal zone by high frequency ventilatory support and pharmacologic reversal of the fetal circulation. The most important causes of death are pulmonary hypoplasia with abnormal pulmonary vascular reactivity and persistent fetal circulation, iatrogenic pneumothorax, interstitial emphysema, mediastinal shifting with subsequent pulmonary hypertension and right to left shunting, and associated cardiac malformations.
 ...
PMID:[Prevention of complications in congenital diaphragmatic defects]. 370 91

During a 14-month period 11 preterm infants were treated with high-frequency jet ventilation for severe respiratory failure that had been unresponsive to conventional mechanical ventilation. Primary indications included intractable air leaks (pulmonary interstitial emphysema, pneumothorax, or both), congenital diaphragmatic hernia, and progressive pneumonia. The Sechrist 990 HFV respirator, a solenoid-driven, pulse-generated high frequency jet ventilator, was used. This device delivers a volume of gas at a controlled pressure to a jet located in the patient connector proximal to a standard single lumen endotracheal tube. The ventilator was operated in tandem with a Sechrist IV-100B ventilator to provide a sigh effect and to improve humidification. Although only 3 of 11 patients survived, 9 displayed short-term benefits from HFJV with significant reduction in mean airway pressure and improvement in mean arterial blood pressure, and no concomitant adverse effects on oxygenation or ventilation. Preliminary results suggest short-term benefits of HFJV in infants who have severe respiratory failure that is unresponsive to conventional mechanical ventilation.
 ...
PMID:Proximal high-frequency jet ventilation of the newborn. 406 16

Is an acute bronchial, obstructive disease of the infant caused mainly by the respiratory syncytial virus. It appears epidemically preceded by infections of the upper respiratory ducts, followed by coughing, dysnea, expiratory sibilants, suprasternal and subcostal during inspiration and radiologic evidences of choneking. In the differential diagnosis the physician must consider pulmonary dysgenesis, diaphragmatic hernia, congenital lobar emphysema, congenital cardiopathy, pneumothorax, obstruction due to foreign body, asthmatic crisis and fibrocystic disease. Fundamentally, two diagnoses should be discarded: 1) dyspenic bacterial bronchopneumonic syndrome; 2) prime infection T. B. bronchopneumonia with bronchiolitic syndrome.
 ...
PMID:[Bronchiolitis]. 742 29

The article discusses the x-ray signs seen in 14 babies with unilateral emphysematous expansion. 7 of these infants had a lobar emphysema without any defect of the bronchial cartilage, whereas two had pulmonary cysts, one suffered from a congenital cystic adenomatoid pulmonary malformation, and one infant had been suffering from lymphangiectasy; in all cases, successful lobectomy had been performed. One patient with pneumatocele, one with a left-side agenesia of the upper lobe and one with a transient obstruction of the bronchi by a mucous plug, were given conservative treatment. The article discusses the x-ray differentiation of the following disturbances: pneumothorax, diaphragmatic hernia, compensatory and obstructive emphysematous expansion of a pulmonary lobe, cystic changes in the lung, and lobar emphysema, although this does not offer any possibility of discovering the reason for its occurrence. Attention is drawn to the diagnostic value of bronchoscopy and bronchography, as well as angiography, especially in case of suspected vascular malformation.
 ...
PMID:[X-ray differential diagnosis of unilateral pulmonary emphysematous expansion in newborn and babies (author's transl)]. 744 55

Laparoscopic surgery is growing in popularity. As a result, laparoscopic procedures are being done on a broader and older patient population. These patients may have underlying cardiopulmonary disease that predisposes them to complications not seen in younger patients. Anesthesiologists should be aware of this possibility and of the problems inherent to the pneumoperitoneum necessary for laparoscopy. We present two cases involving elderly patients to illustrate cardiopulmonary complications that can occur during establishment or maintenance of the increased intra-abdominal pressures required for laparoscopic surgery. The first case describes a patient who developed bradycardia and asystole during insufflation for a laparoscopic hernia repair. The second case involves severe hypercarbia and a pneumothorax due to massive subcutaneous emphysema that developed during a laparoscopic colon resection.
 ...
PMID:Cardiopulmonary complications during laparoscopy: two case reports. 748 67


<< Previous 1 2 3 4 5 6 7 8 Next >>