Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019270 (hernia)
 15,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

3865 consecutive newborns delivered between 2/1/91 and 7/31/93 were prospectively studied. All the neonates received a physical examination during the first 24 hours of life. Major congenital anomalies (MCA) were found in 64 newborns at incidence of 16.5/1000 births. 61 patients with full description included 40 with single and 21 with multiple MCA. Out of the latter 2 had syndromal (Osteogenesis Imperfecta and Achondroplasia), 16 nonsyndromal and 3 sequence multiple (Pierre Robin, diaphragmatic hernia with dextrocardia and breech presentation sequence) malformations. Skeletal anomalies were leading among the group (46.29%), followed by genitourinary (GU) defects (12.14%) and neural tube fusion defects (NTFD) (11.21%). Incidence of low birth weight (LBW) was 6% among the studied group of newborns and 26.56% among the group with MCA. Incidence of MCA among the group of LBW was 7.32%. While 65.62% of cases were amenable to surgery the malformed infants formed 24.34% of all perinatal death suggesting that improved care given to these patients will appreciably participate in reducing perinatal mortality. Incidence of NTFD (3.10/1000 births) was higher than in many western and middle eastern reports suggesting the need for further testing for incidence and etiology. Among the malformed infants, the rate of low birth weight and the rate of parental first cousin consanguinity were significantly higher than corresponding rates among normal infants in a control group.
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PMID:Major congenital malformations presenting in the first 24 hours of life in 3865 consecutive births in south of Beirut. Incidence and pattern. 1034 59

A case is described of a 47-year-old man with achondroplasia who presented with lower back pain radiating to his left loin. An intravenous urogram (IVU) showed hydronephrosis on the left side and a dilated left ureter passing down into the left inguinal region. A CT scan confirmed a left inguinal hernia containing the left ureter causing ureteric obstruction. The hernia was repaired using the Lichtenstein technique with the ureter replaced retroperitoneally. A postoperative IVU showed recovery in renal function but with a persistently dilated left ureter that was not obstructed. A review of the literature regarding inguinal herniation involving the ureter is presented.
Hernia 2003 Jun
PMID:An unusual cause of back pain in an achondroplastic man. 1282 33