Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
She 273
Sep 268
lymphoid 174
hemoglobin 145
CD4 138
ferritin 124
CD8 123
alkaline phosphatase 93
glucocerebrosidase 89
lactate dehydrogenase 74
Mol 73
cytokine 66
CD56 65
CD20 62
CD5 60
LDH 54
HLA 54
erythroid 49
HLA-DR 48
IgA 47
MRI 46
non-Hodgkin's lymphoma 46
CD2 43
fibrinogen 42
CD7 42
imiglucerase 40
C-reactive protein 37
CD19 36
interferon 36
CD10 33
perforin 33
CHOP 33
nodal 32
CD68 32
thymus 31
IgE 31
TCR 28
natural killer cell 27
prothrombin 26
CD30 26
ESR 26
aspartate aminotransferase 26
CD13 26
AML 25
NPC1 25
collagen 25
acid sphingomyelinase 24
CD34 24
CD33 24
interleukin-6 24
white cell 24
SLAM-associated protein 23
acid phosphatase 23
CSF 23
alanine aminotransferase 22
Fas 22
CD25 22
membrane-bound 22
glucosidase 22
albumin 22
lipase 22
IgG3 21
IL-6 21
myeloperoxidase 21
mast cell 21
CD16 20
interleukin-2 receptor 20
CD1a 20
insulin 20
HDL 19
tumor necrosis factor 19
esterase 19
CD45 18
ALL 18
severe combined immunodeficiency 18
IFN 18
JAK2 18
lysozyme 17
lysosomal acid lipase 17
PRF1 17
TNF 17
Polymerase 17
FDG 17
tap 17
peroxidase 17
CRP 17
X-linked 17
Munc13-4 16
Pol 16
B12 16
MPS II 15
CD38 15
NPC2 15
granulocyte 15
thromboplastin 15
IL-4 15
erythropoietin 15
IL-10 14
FAB 14
chitotriosidase 14
T cell receptor 14
beta-glucuronidase 14
CD14 14
CD57 14
CD23 14
interferon-gamma 13
granzyme B 13
rheumatoid factor 13
neuraminidase 13
granulocyte colony-stimulating factor 13
lipoprotein lipase 13
AST 13
B19 13
CLL 12
S100 12
membrane protein 12
serum albumin 12
CD79a 12
RAG1 11
p13 11
LIPA 11
IL-2 11
ANA 11
mevalonate kinase 11
bcr 11
SLC7A7 11
TIA-1 11
IFN-gamma 11
alpha-L-iduronidase 10
TdT 10
CD15 10
interferon-alpha 10
factor VIII 10
sulfatase 10
interleukin-2 10
axonal 10
Ki-1 10
endoplasmic reticulum 10
beta-globin 10
CD117 10
SMPD1 10
M-protein 10
RAB27A 10
MPS VI 9
FAS 9
megakaryocyte 9
CML 9
A-I 9
T-cell receptor beta 9
sialidase 9
STX11 9
serum protein 9
CD1 9
SLC29A3 9
transferrin receptor 9
granulocyte-macrophage colony-stimulating factor 8
gut 8
macrophage colony-stimulating factor 8
glycoprotein 8
Bcl-2 8
more...
Disease
lymphadenopathy 1093
anemia 749
pancytopenia 498
thrombocytopenia 481
lymphoma 427
cancer 350
leukemia 299
rash 259
tumor 236
Epstein 229
hemophagocytic lymphohistiocytosis 204
Gaucher disease 195
immunodeficiency 155
leishmaniasis 154
HIV 137
cytomegalovirus 134
sepsis 122
kala-azar 117
pneumonia 115
schistosomiasis 112
T-cell lymphoma 112
coagulopathy 111
tuberculosis 110
AIDS 105
Hodgkin's disease 103
sepsis 103
arthritis 102
hepatitis 102
cirrhosis 99
lymphocytosis 98
EBV infection 95
malaria 95
failure to thrive 95
Niemann-Pick 92
acute myeloid leukemia 88
hemolytic anemia 87
myelofibrosis 87
acute lymphoblastic leukemia 83
infectious diseases 80
B-cell lymphoma 77
portal hypertension 75
infectious mononucleosis 73
eosinophilia 72
rare disease 71
systemic lupus erythematosus 71
liver disease 68
myeloproliferative disorders 64
multiple myeloma 63
hypergammaglobulinemia 61
leukopenia 61
virus infection 60
neutropenia 60
cholestasis 59
disseminated intravascular coagulation 59
familial hemophagocytic lymphohistiocytosis 59
proteinuria 58
chronic myeloid leukemia 58
sarcoidosis 57
dysplasia 56
hypercalcemia 56
mental retardation 55
osteopetrosis 55
histoplasmosis 54
chronic lymphocytic leukemia 53
non-Hodgkin's lymphoma 52
mental retardation 52
thalassemia 51
lysosomal storage disease 50
Mycobacterium 49
acute leukemia 49
renal failure 48
primary myelofibrosis 46
brucellosis 46
NPC 45
petechiae 45
vasculitis 45
polyneuropathy 44
POEMS syndrome 43
hyperbilirubinemia 43
respiratory failure 43
interstitial pneumonia 42
hypertension 42
myelodysplastic syndrome 42
diabetes 42
gammopathy 41
Schistosoma mansoni 40
Down syndrome 40
hypofibrinogenemia 40
thrombocytosis 39
hypersplenism 39
developmental delay 39
Infection 38
chronic lymphocytic leukemia 38
heart failure 38
renal disease 37
esophageal varices 37
pruritus 36
hyperlipidemia 35
lymphoproliferative disorders 34
Castleman's disease 34
purpura 34
macroglobulinemia 34
nephrotic syndrome 34
adult T-cell leukemia/lymphoma 34
lymphadenitis 33
autoimmune disease 33
Langerhans cell histiocytosis 33
bone disease 33
mucopolysaccharidosis 33
glomerulonephritis 32
amyloidosis 32
fits 32
graft-versus-host disease 30
meningitis 30
peripheral neuropathy 30
syphilis 29
mastocytosis 29
polyclonal hypergammaglobulinemia 29
encephalopathy 29
sarcoma 29
deafness 28
autoimmune hemolytic anemia 28
fungal infection 28
hydrocephalus 28
Macrophage activation syndrome 27
congenital syphilis 27
osteosclerosis 27
erythroderma 27
osteoporosis 26
metastases 26
pulmonary hypertension 26
hypogammaglobulinemia 26
lupus 26
pericardial effusion 26
T-cell lymphomas 26
Still's disease 25
Budd-Chiari syndrome 25
systemic disease 25
renal insufficiency 25
rheumatoid arthritis 25
toxoplasmosis 25
angioimmunoblastic T-cell lymphoma 24
rubella 24
malnutrition 23
hypertrichosis 23
lymphopenia 23
opportunistic infection 23
juvenile myelomonocytic leukemia 23
Wolman disease 23
West 22
chronic neutrophilic leukemia 22
Hurler 21
panniculitis 21
myocarditis 21
immune deficiency 21
genetic disorder 21
hematologic malignancies 21
Kaposi's sarcoma 21
acute renal failure 21
hypothyroidism 21
more...
Symptom
hepatosplenomegaly 4408
splenomegaly 193
abdominal pain 145
hepatomegaly 140
diarrhea 139
pallor 117
fatigue 116
cough 92
weakness 85
vomiting 81
Ill 73
headache 67
seizures 66
arthralgia 64
dyspnea 63
anorexia 63
respiratory distress 62
pain 58
fever of unknown origin 56
hypotonia 51
chills 38
sore throat 33
lethargy 33
bone pain 32
ataxia 30
night sweats 30
myalgia 26
nausea 25
erythema 25
cachexia 23
shortness of breath 19
tachypnea 19
back pain 15
myoclonus 15
clubbing 15
asthenia 13
dystonia 12
chest pain 12
discomfort 11
sleepiness 11
discomfort 11
abdominal discomfort 11
dysarthria 10
ophthalmoplegia 10
cerebellar ataxia 10
constipation 10
oliguria 9
anesthesia 9
rales 9
hemoptysis 9
joint stiffness 9
exertional dyspnea 9
dizziness 9
paresis 8
blurred vision 8
flushing 8
collapse 8
rigors 8
right upper quadrant pain 7
chronic cough 7
spasticity 7
cyanosis 7
hypertonia 7
paresthesia 6
hypoproteinemia 6
tremor 6
emaciation 6
low back pain 6
regurgitation 6
leg edema 6
adenitis 6
clumsiness 5
ENT 5
pedal edema 5
epigastric pain 5
generalized rash 5
rhinorrhea 5
angina 5
productive cough 4
vertigo 4
livedo 4
wheezing 4
paraparesis 4
tense 4
numbness 4
hemiplegia 4
abdominal fullness 3
tonic-clonic seizure 3
nausea and vomiting 3
dark urine 3
acute abdomen 3
decreased appetite 3
photophobia 3
overweight 3
leg pain 3
hoarseness 3
lassitude 3
dysesthesia 3
intestinal bleeding 3
eye discharge 2
Physical findings 2
intention tremor 2
polyuria 2
analgesia 2
knee pain 2
Kayser-Fleischer ring 2
acute abdominal pain 2
consciousness disturbance 2
Neurologic symptoms 2
General symptoms 2
excessive sweating 2
thinning 2
neck pain 2
swollen joints 2
apathy 2
snoring 2
persistent cough 2
Gastrointestinal symptoms 2
nasal discharge 2
Decreased activity 2
starvation 2
Darier's sign 1
dysuria 1
syncope 1
otalgia 1
Fatigability 1
tinnitus 1
dysosmia 1
torticollis 1
enuresis 1
belching 1
Palmar erythema 1
decreased skin turgor 1
memory loss 1
hypersomnia 1
HSA 1
flank pain 1
generalized abdominal pain 1
abnormal gait 1
S3 gallop 1
periorbital edema 1
dyschezia 1
pachyonychia 1
athetosis 1
stigma 1
dry eye 1
prostration 1
insomnia 1
elbow pain 1
skin damage 1
Cutaneous anergy 1
lightheadedness 1
labored breathing 1
incoordination 1
polydipsia 1
unable to sleep 1
exhaustion 1
muscle stiffness 1
abdominal cramps 1
hypalgesia 1
more...
Drug
Dermatol 98
CSF 27
IL-2 11
IFN-gamma 11
Rituximab 10
G-CSF 8
Asthma 8
lysine 7
Tocilizumab 7
Cerezyme 7
MDS 7
Prednisone 6
Ceredase 6
Prednisolone 6
ampicillin 5
ENT 5
Cardiovasc 5
Fansidar 5
Pentostam 5
Glucantime 5
Ganciclovir 5
Cerezyme 5
Fansidar 5
Miglustat 5
vitamin E 5
Adriamycin 5
CTX 5
Portal 4
CTX 4
Methylprednisolone 4
Kenyan 4
Tuberculin 4
Dial 4
lactose 4
Trib 3
NBT 3
Vitamin B12 3
CTX 3
Miltefosine 3
PTH 3
Indomethacin 2
Leaf 2
Idursulfase 2
Anakinra 2
BCG vaccine 2
Bactrim 2
Simvastatin 2
Etoposide 2
Acyclovir 2
Growth hormone 2
Meth 2
Itraconazole 2
AmBisome 2
Growth hormone 2
Galsulfase 2
Paraffin 2
IL-1ra 2
Filgrastim 2
Fludarabine 2
CFT 2
Filgrastim 2
Eculizumab 1
Nephron 1
Ambisome 1
DEX 1
Hypaque 1
Azithromycin 1
Epoetin alfa 1
Gastro 1
Monit 1
Dasatinib 1
Infliximab 1
Lariam 1
Lactase 1
CDP 1
Aldurazyme 1
Myozyme 1
Infliximab 1
Lariam 1
AZT 1
ADR 1
Hypaque 1
AMC 1
AIC 1
Maribavir 1
Cidofovir 1
Engerix-B 1
ascorbate 1
AHF 1
beta-Galactosidase 1
Lovastatin 1
Ketoconazole 1
Vitamin B 1
L-Asparaginase 1
Epoetin 1
Albumin 1
Imatinib 1
Claforan 1
Aldurazyme 1
-deoxyadenosine 1
Gabexate mesilate 1
caffeine 1
TAT 1
Fabrazyme 1
Retinoic acid 1
ROC 1
Gel 1
niacin 1
Fursultiamine 1
Isotretinoin 1
VCR 1
AZT 1
ARA-C 1
ROS 1
linolenate 1
Lugol's solution 1
Bortezomib 1
TEL 1
AraC 1
Nephron 1
FeCl3 1
Enzyme
alkaline phosphatase 93
lactate dehydrogenase 83
glucocerebrosidase 77
alanine aminotransferase 42
peroxidase 38
aspartate aminotransferase 35
CD10 33
focal adhesion kinase 30
CD13 26
neuraminidase 25
lipase 23
acid phosphatase 23
ERK 22
beta-galactosidase 19
lysozyme 17
thromboplastin 15
gamma-glutamyl transpeptidase 14
granzyme B 13
sulfatase 13
lipoprotein lipase 13
ACE 12
AST 12
mevalonate kinase 11
asparaginase 10
alpha-L-iduronidase 10
iduronate-2-sulfatase 10
TdT 10
mitogen-activated protein kinase 9
BMT 9
sialidase 9
reverse transcriptase 9
beta-glucosidase 8
beta-glucosidase 8
branching enzyme 7
beta-glucuronidase 7
creatine kinase 6
catalase 6
tryptase 6
trypsin 6
alpha-mannosidase 6
hexosaminidase 6
plasmin 5
chondroitinase 5
RNA polymerase 5
ceruloplasmin 5
carboxylesterase 4
glucosylceramide synthase 4
APC 4
neutral sphingomyelinase 4
transcriptase 4
thrombin 3
transaldolase 3
glucose-6-phosphate dehydrogenase 3
caspase-3 3
arylsulfatase A 3
endonuclease 3
carboxypeptidase Y 3
MDP 3
ATPase 3
pyruvate kinase 3
uridyltransferase 3
acyloxyacyl hydrolase 2
transglutaminase 2
farnesyltransferase 2
farnesyltransferase 2
5'-nucleotidase 2
aldolase 2
chalcone synthase 2
galactokinase 2
phosphoglucomutase 2
mannanase 2
fumarylacetoacetate hydrolase 2
cathepsin G 2
protein kinase 2
P-glycoprotein 2
coproporphyrinogen oxidase 2
DCF 2
protein kinase C 2
phosphorylase kinase 2
ceramidase 2
cholesterol acyltransferase 2
LPL 2
biotinidase 2
phosphatidylinositol 3-kinase 1
glutathione synthetase 1
pyruvate dehydrogenase 1
arylsulfatase 1
NADPH oxidase 1
acetylcholinesterase 1
chondroitinase 1
renin 1
alpha-L-fucosidase 1
thyroid peroxidase 1
transpeptidase 1
phosphoinositide 3-kinase 1
heme oxygenase 1
pyruvate dehydrogenase 1
adenosine deaminase 1
cholinesterase 1
phosphoglucose isomerase 1
aspartylglucosaminidase 1
elastase 1
adenosine deaminase 1
LasR 1
transketolase 1
HSD 1
3-hydroxyacyl-CoA dehydrogenase 1
phosphomannomutase 1
CPT 1
prolidase 1
cholesterol esterase 1
cytochrome oxidase 1
histone-lysine N-methyltransferase 1
MCS 1
alpha-glucosidase 1
phosphoglycerate kinase 1
NADPH oxidase 1
calcineurin 1
TAT 1
coproporphyrinogen III oxidase 1
legumain 1
BMA 1
ALA synthase 1
superoxide dismutase 1
monoacylglycerol lipase 1
porphobilinogen deaminase 1
galactocerebrosidase 1
tissue plasminogen activator 1
N-acetyltransferase 1
STR 1
3-hydroxyacyl-CoA dehydrogenase 1
urokinase-type plasminogen activator 1
glucose-6-phosphatase 1
GTI 1
cathepsin K 1
complex I 1
phosphodiesterase 1
TPP 1
dihydropyrimidine dehydrogenase 1
proteasome 1
prostate-specific antigen 1
glutamate dehydrogenase 1
CPT 1
type III procollagen 1
CPT 1
topoisomerase 1
pyruvate dehydrogenase 1
glutamic dehydrogenase 1
p80 1
glutamate dehydrogenase 1
PGM 1
CNPase 1
topoisomerase 1
adenylate kinase 1
5-oxoprolinase 1
phosphofructokinase 1
glutamate dehydrogenase 1
DNA methyltransferase 1
monoamine oxidase 1
DNA polymerase 1
more...
Compound
Clin 361
Dec 313
DNA 201
His 109
iron 42
sodium 37
creatinine 33
glucose 28
calcium 28
oxygen 26
A 3 25
sulfate 24
Hemoglobin 24
galactose 19
leucine 19
VP-16 17
TNF 17
acetate 17
water 16
phosphate 16
PAS 15
urea 14
Guo 14
Guo 14
BCG 13
Amphotericin B 13
A 42 13
zinc 13
ANA 11
Isoproterenol 11
ANA 11
Cardiol 11
Ara-C 10
A 1 10
tyrosine 9
lysine 9
arginine 9
copper 9
Ara-C 9
MTX 8
Cyclosporine 8
Methotrexate 8
methionine 8
vitamin D 8
Cholesterol 7
PPD 7
BCR 7
nitrogen 7
ornithine 7
PPD 7
silver 7
nitric oxide 7
ornithine 7
TSH 7
ornithine 7
ornithine 7
ammonia 7
ornithine 7
Praziquantel 7
DIC 7
ABL 6
FDP 6
Prednisolone 6
potassium 6
Prednisone 6
ALP 6
Adriamycin 6
iodine 6
GPT 6
DTPA 5
CTX 5
bis(2-chloroethyl) 5
Phe 5
DBA 5
Pac 5
Parenteral 5
NNN 5
DBA 5
Rifampicin 5
DBA 5
cysteine 4
Dial 4
Methylprednisolone 4
GM1 4
serine 4
retinoic acid 4
proline 4
GalNAc 4
COS 4
A 71 4
ATP 4
Busulfan 4
TEM 3
Thyroid 3
Congo red 3
2,4-DNT 3
GSH 3
threonine 3
ACTH 3
CD 3 3
CDA 3
Belt 3
alanine 3
THP 3
GSH 3
AZT 3
Ceftriaxone 3
phosphorus 3
titanium 3
DSS 3
GlcNAc 3
CO2 3
N-acetylcysteine 3
NBT 3
Reticulin 3
chloroform 3
PEG 3
THP 3
methanol 3
keratan sulfate 3
manganese 2
ADP 2
Lac 2
Asp 2
pentose 2
glutamine 2
aspartic acid 2
L-PAM 2
glutamate 2
Neu5Ac 2
BAL 2
pentose 2
Penicillin 2
Filipin 2
DMP 2
valine 2
Lactate 2
pyrimidine 2
aspartic acid 2
PEG 2
Acyclovir 2
ADR 2
pyrimidine 2
TAR 2
aspartic acid 2
Toluidine blue 2
aspartic acid 2
CAT 2
Penicillin 2
DPH 2
5-Aza-2'-deoxycytidine 2
DMP 2
THE 2
MCNU 2
CoA 2
4-hydroxyphenylpyruvate 2
MMA 2
L-PAM 2
CAT 2
ANCA 2
more...