Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult T-cell leukemia (ATL) is a leukemia caused by a monoclonal expansion of HTLV-I-infected T-cells expressing a CD4 antigen. The clinical features of ATL include lymphadenopathy, hepatosplenomegaly, frequent skin lesions, hypercalcemia and a rapidly fatal course. The cell surface phenotype, cytogenetics and functions of leukemic cells are described in association with various clinical manifestations and HTLV-I infection. Leukemic cells constitutively express the p55 (Tac antigen) subunit of the interleukin-2 (IL-2) receptor. Its association with the function of HTLV-I gene products and its possible role in the leukemogenesis of ATL are discussed. Finally, the potential of some therapeutic agents which may selectively eliminate the Tac-expressing leukemic cells in vitro are described, and these may provide an improvement over currently ineffective combination chemotherapy.
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PMID:Adult T-cell leukemia. 306 29

A 46-year-old man with primary myelofibrosis developed polyarthralgia. Marked hepatosplenomegaly was noted, and hematological examinations revealed a white cell count of 25,600/microliters with 42% promyelocytes and thrombocytopenia. The promyelocytes were positive for CD4 antigen and nonspecific esterase as well as peroxidase. Cytogenetic analysis of circulating mononuclear cells showed the trisomy of No. 22 chromosome in 3 of 5 cells examined. Four months later, the patient became asymptomatic, and hematological picture and hepatosplenomegaly returned to the original level. This is the first report describing the transient promyelocytic expansion in myeloproliferative disorders.
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PMID:[Transient promyelocytic expansion in primary myelofibrosis]. 756