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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

90 patients diagnosed as eosinophilia and pulmonary infiltrates with peripheral eosinophilia in PUMC Hospital from 1957 to 1986 were reported. The cause of the eosinophilia was unknown in 42% of the patients. Among these patients, hypereosinophilic syndromes (HES) were suspected in 11 patients. The most common presenting symptoms of HES were fever, skin lesions gastrointestinal symptoms and hepatosplenomegaly, the mean peripheral blood eosinophil count was as high as 25.6 x 10(9) cells/L. Biopsies of bone marrow and involved organs revealed extensive eosinophilic infiltration and severe necrosis. In the past ten years, eosinophilia and pulmonary infiltrates caused by parasitic infections obviously decreased. The most common parasites were ascaris Lumbricoides, Ancylostoma duodenale and Clonorchis sinesis. The other main causes which induced pulmonary infiltrates were allergic bronchopulmonary mycosis (ABPM) and chronic eosinophilic pneumonia. The prevalence of ABPM increased recently; early diagnosis and effective therapy could prevent the irreversible damage resulting in airways obstruction and fibrosis.
Zhonghua Nei Ke Za Zhi 1990 Nov
PMID:[Clinical analysis of 90 cases of eosinophilia and pulmonary infiltrates with peripheral eosinophilia]. 208 6

The clinical characteristics of hepatic tuberculosis in 52 cases diagnosed pathologically were analyzed. Fever, abdominal pain and hepatomegaly were the major clinical manifestations; they were present in 96.2%, 42.3% and 88.5% of the patients respectively. The fever had no consistent pattern and the abdominal pain was usually localized to the right hypochondrium and not related to overwork. Hypergrammaglobulinaemia, elevated alkaline phosphatase level and increased ESR were noted in most of the patients (76.9%, 75.0%, 76.5% respectively). 62.5% of the 52 patients was diagnosed by percutaneous liver biopsy. Since there is no consistent clinical pattern in patients with hepatic tuberculosis, the diagnosis should be considered in patients with unexplained fever associated especially with hepatomegaly or hepatosplenomegaly, elevated alkaline phosphatase level, hypergrammaglobulinaemia and increased ESR, Liver biopsy is the most valuable method to confirm the diagnosis of hepatic tuberculosis.
Zhonghua Nei Ke Za Zhi 1995 Jan
PMID:[Clinical characteristics of hepatic tuberculosis]. 760 Aug 75

A case of Armillifer agkistrodontis disease was reported. Armillifer agkistrodontis is a species of the Armillifer genus of the Linguatulida order and parasitizing agkistrodon acutus. According to literature reviewed, there has been no report of this disease caused by infection of Armillifer agkistrodontis in human being prior to this case all over the world. The clinical features of this disease are long-term high fever, abdominal pain, diarrhea, mild anemia, hepatosplenomegaly, eosinophilia in bone marrow and blood and multiple polyps in the whole colon. The pathologic features of the liver biopsy was degeneration and necrosis of hepatocytes and obvious infiltration of eosinophils. This disease should be differentiated from several other diseases which can also cause hepatomegaly, long-term high fever, abdominal pain and diarrhea. Mebendazole is an effective medication for this disease, but the long term effect of praziquantel is not certain. It is necessary to make further studies on the epidemiology, etiology, pathology, natural history, clinical features, diagnosis, differential diagnosis and therapy of this disease.
Zhonghua Nei Ke Za Zhi 1996 Nov
PMID:[Armillifer agkistrodontis disease: report of case]. 959 42

To determine the chromosomal abnormalities and their clinical significance in adult acute lymphoblastic leukemia, karyotypic analyses with R- and/or G-banding were performed in 101 newly diagnosed ALL patients. The results showed that 69 (68.32%) cases had clonal chromosomal abnormalities and specific abnormalities including Philadelphia chromosome (32.67%), t(4;11) (2.97%), t(11;14) (3.96%), abnormalities of 8q24 (2.97%), 6q- (4.96%). Patients with Ph chromosome showed higher leukocyte counts and more frequent hepatosplenomegaly and most of them were L2 and B lineage subtypes. They had lower complete remission (CR) rate, needed longer time to achieve CR and relapsed earlier as compared with patients without Ph chromosome. These suggested that chromosomal abnormalities are very frequent and some specific abnormalities had specific clinical features.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia in adults]. 1037 15