Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Active cytomegalovirus (CMV) infections were found in 91 infants (11%) examined in the Department of Virology from 1988 to 1992. Serological methods (ELISA, CFT) and virus isolation from urine were used to diagnose CMV infection. Congenital or perinatal infections were recognized in 20 infants, while 10 infants were infected by blood transfusion. In most cases the route of CMV transmission was not recognized. The occurrence of clinical symptoms in CMV-infected children was also studied. In 80% of the infants the disease was characterized by hepatosplenomegaly or liver dysfunction. CMV pneumonia was found in 41% of the cases, and gastroenterocolitis in 36% of the subjects.
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PMID:[Cytomegalovirus infections in infants examined in the department of virology in 1988-1992]. 823 34

A newborn with symptoms of congenital cytomegalovirus infection (interuterine dystrophy, thrombocytopenia, leukopenia, hepatosplenomegaly, chronic pneumonia, pleocytosis in CSF) is described in whom tests for specific anti- CMV-IgM antibodies were negative. Changes typical for cytomegaloviral infection were found on autopsy. The authors discuss the difficulties in interpreting various serologic tests (CFT, anti-CMV IgM) in congenital infections, suggesting the necessity of introducing new diagnostic methods for better diagnosis and treatment.
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PMID:[Suppression of immunological response in a newborn with congenital cytomegalovirus infection: diagnostic difficulties]. 897 25