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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There have been many relevant advances in our knowledge of triglycerides as they apply to clinical medicine. Some of the basic concepts of triglyceride metabolism are reviewed in a context of clinical applicability. Hypertriglyceridemia may be associated with dramatic symptoms and signs such as acute abdominal pain, hepatosplenomegaly, and neuromuscular abnormalities, or it may be asymptomatic until an atherosclerotic complication occurs. There is an increased risk of atherosclerosis with elevated endogenous triglycerides, but it is not clear if this is due to triglycerides per se, or the cholesterol content of the common lipoprotein that transports both lipids. Serum triglycerides are affected by diverse underlying disorders. Several factors play a role in the pathogenesis of hypertriglyceridemia including diet, body weight, genetic influences, glucose metabolism, and insulin concentrations. Treatment by diet and/or drugs is quite effective in relieving many of the clinical manifestations of hypertriglyceridemia. Whether a beneficial effect also occurs in atherosclerosis is still unknown.
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PMID:Triglycerides in clinical medicine. A review. 67 84

We present a case of a 4-year-old girl with abdominal angiostrongyliasis who presented with persistent fevers, hepatosplenomegaly, acute abdominal pain, and eosinophilia. Computed tomography scan identified thickening of the ascending colon with a narrowed lumen. Endoscopic evaluation revealed ulcerations and erythema in the ascending colon. The microscopic findings in biopsies included active chronic inflammation with prominent eosinophils and granulomas. A subset of granulomas contained the eggs of Angiostrongylus costaricensis. The definitive method of diagnosing A costaricensis is histology; peripheral blood serology has low specificity and the stool from infected patients does not contain eggs or larvae. Pathologists from endemic regions (Central and South America) are familiar with the typical histologic changes; however, because of increasing global travel, all pathologists should become familiar with A costaricensis, which may mimic common gastrointestinal diseases such as Crohn's disease, appendicitis, and Meckel's diverticulum.
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PMID:Abdominal Angiostrongyliasis: A Presentation of Eosinophilic Granulomatous Colitis. 2927 74