Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Significant portion of the urologic and nephrologic patients in Yemen are treated because of the early and late complications of schistosomiasis (bilharsiasis). During two years 79 patients with renal insufficiency and complications have been examined and treated by the authors. In combination with moderate restricted renal functions hepatosplenomegaly and signs of portal hypertension were observed in female patients. Granulomatous infiltration, calcification and malignous tumour of the urinary bladder was found in men. Stricture of the ureter, uni- or bilateral consecutive hydronephrosis was detected frequently. In addition to inflammatory components bladder, ureteral and renal stones were verified. In the course of treatment 45 percutaneous nephrostomies were performed and an anterograde pyelography was carried out in 60 patients. Ureteral recanalisation was accomplished by means of an ureter stent in 8 cases. Because of serious uremia maintenance haemodialysis was performed in 52 patients. The aim of this work is to contribute to recognise the disease in early stage and emphasize the importance of establishing diagnosis as early as possible and stress the role of the appropriate causal and symptomatic treatment.
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PMID:[Late urinary tract complications of schistosomiasis]. 181 Dec 3

We report a case of a 22 years old type 1 diabetic man with a history of weight loss, weakness, anorexia, fever and recurrent urinary tract infection since February 2001. In April 2001, he presented anuria due to obstructive acute renal failure. Hepatosplenomegaly and lymphadenopathy were absent at physical examination. Laboratory tests revealed a high level of gamma globulin (53.4 g/l) and anaemia (haemoglobin 7.7 g/100 ml) without leukopenia and thrombocytopenia. CT scan showed multiple retroperitoneal lymphadenopathies causing compression of the two ureters, hydro-ureter associated with hydronephrosis, hepatosplenomegaly and multiple pulmonary nodes. Lymphadenopathies, anaemia, high level of gamma globulin, high titres of anti-leishmanial antibodies and the excellent outcome after treatment with meglumine antimoniate (Glucantime) confirmed visceral leishmaniasis. This report documented an unusual clinical presentation of Visceral leishmaniasis in a diabetic patient.
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PMID:[Obstructive acute renal failure revealing visceral leishmaniasis in a diabetic patient]. 1272 15