Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019214 (
hepatosplenomegaly
)
4,408
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Essential mixed cryoglobulinemia
(
EMC
) is a syndrome characterized by cryoglobulinemia and clinical features including purpura, arthralgia, asthenia (Meltzer-Franklin syndrome) without evidence of any systemic disease Liver involvement in the course of
EMC
is described in 50-84% of patients. It consists of mild silent
hepatosplenomegaly
and slightly rise of serum amino transferase. Eleven patients with clinical and laboratory findings suggestive for
EMC
(five type II and six type III) underwent percutaneous liver biopsy to evaluate the degree of liver involvement. Two liver cirrhosis, two chronic active hepatitis, one chronic persistent hepatitis and a case of hepatic steatosis were found. A type III cryoglobulinemia was present in four of the six patients with liver involvement. All the patients were Hbs Ag negative but three of them were Hbs Ab positive. The pathogenesis of liver involvement in the course of
EMC
is still now uncertain. The authors believe that a previous HBV infection plays no role in the pathogenesis of
EMC
syndrome. This syndrome must be considered different from mixed cryoglobulinemia secondary to chronic liver disease. They suggest that liver biopsy is mandatory during the course of
EMC
even when clinical and laboratory data are silent.
...
PMID:[Essential mixed cryoglobulinemia with liver involvement: a still open problem]. 238 52
