Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An auspsied case of malignant fibrous histiocytoma (MFH) is reported. The patient, a 53-year-old male had developed splenomegaly 1 year before admission. On admission, hepatosplenomegaly and ascites were seen, with prominent leucocytosis in the peripheral blood, and the patient died of cachexia. On autopsy, the primary neoplasma was found in the spleen, with metastasis to the liver, vertebrae, lymph nodes and peritoneum. Histologically, to tumor showed a storiform arrangement of tumor cells, with foamy or hemosiderin-faden cytoplasm in places, corresponding to MFH. As far as we know, there have been no reports of primary MFH of the spleen in Japan.
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PMID:[An autopsied case of malignant fibrous histiocytoma of the spleen]. 359 82

A transgenic mouse strain with the zeta-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.
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PMID:Multiple tumor types appear in a transgenic mouse with the ras oncogene. 847 93