Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A one and half a month-old infant, a female, was brought to this hospital with the chief problem of diarrhea lasting for more than one week. Four days after admission, symmetric and nonpruritic lichenoid papules developed over her face and limbs. Physical examination showed several small palpable lymph nodes over the bilateral inguinal areas, but without hepatosplenomegaly. Gianotti-Crosti syndrome was diagnosed. Latter on, cytomegalovirus (CMV) was isolated from urine and throat swab. It seemed that this case of Gianotti-Crosti syndrome was associated with CMV infection.
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PMID:Gianotti-Crosti syndrome associated with cytomegalovirus infection: report of one case. 779 81

A boy aged 2 years and 10 months had a pruritic eruption and low-grade fever for 1 week. Examination revealed discrete erythematous papules and papulovesicles on his buttocks and extensor surfaces of four limbs. Several papules were also present on his back. No lymphadenopathy and no hepatosplenomegaly were noted. Investigations failed to identify a single viral aetiology. Topical calamine lotion and a sedating oral antihistamine to be taken at night were prescribed. The truncal lesions subsided in 3 weeks. Complete remission of all lesions was seen after 6 weeks. Although most patients with Gianotti-Crosti syndrome only have the typical acrally distributed eruption, additional truncal lesions, if few in number, do not exclude the diagnosis.
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PMID:Truncal lesions do not exclude a diagnosis of Gianotti-Crosti syndrome. 1286 49

Gianotti-Crosti syndrome (GCS) is a sporadic dermatosis affecting mainly children. It is characterized by multiple, confluent, monomorphic and pruritic pink to red-brown papules or papulovesicles, distributed symmetrically on the face, extensor surfaces of the extremities and buttocks, commonly sparing the trunk, palms and soles. This can be preceded by a viral infection, and may be accompanied by fever, hepatosplenomegaly, or lymphadenopathy. Personal and family history of atopy appears to be a risk factor in the subsequent development of GCS, thus frequently diagnosed as atopic dermatitis. We report a case of a 4-year-old boy from our institution with generalized, pruritic, papulovesicular rashes on the face and extremities for one month. He was diagnosed to have atopic dermatitis and treated as such, before presentation to our institution. As the signs and symptoms in GCS are similar to atopic dermatitis, we suggest that this diagnosis be considered when presented with a similar case.
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PMID:Gianotti-Crosti syndrome: case report of a pruritic acral exanthema in a child. 2287 25