Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In endemic hepatosplenomegaly with histopathologically proved atrophic gastritis, the gastric juice carcinoembryonic antigen (CEA) showed significant increase. Comparing this group of patients with histopathologically proved gastric neoplasia the levels were significantly higher in the later group. The level of (CEA) was only increased in 75% of cases with endemic hepatosplenomegaly and atrophic gastritis opposite to 100% of cases with gastric neoplasia. The level of serum (CEA) was also studied in patients and control groups. In patients with endemic hepatosplenomegaly and atrophic gastritis the level was insignificantly higher than the control group and significantly lower than the group with gastric neoplasia.
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PMID:Evaluation of gastric carcinoembryonic antigen in endemic schistosomal hepatosplenomegaly. 223 Mar 10

Here we report an unusual case of T-cell lymphoma presenting as ascites. A 49-yr-old woman was admitted to the hospital for abdominal discomfort associated with increasing abdominal girth over the course of 3 mo. She also complained of nausea, vomiting, and diarrhea. On physical examination, a tense and distended abdomen and edema of the lower extremities were noted. Neither hepatosplenomegaly nor lymphadenopathy was found. A CT scan of the abdomen and pelvis showed a large abdominal/pelvic mass surrounding the small bowel and omentum and small nodes in the para-aortic and mesenteric regions. The cytospin prepared from the peritoneal fluid was hypercellular and composed of a population of monotonous, noncohesive cells with a high nuclear/cytoplasmic ratio and a single prominent central nucleolus. The cells were positive for leukocyte common antigen and Leu-22 (CD43) but negative for keratin, L26, UCHL-1, kappa, lambda, CD3, Ki-1 (CD30), S-100, and carcinoembryonic antigen. Morphologic and immunologic findings were suggestive of T-cell immunoblastic lymphoma. Peripheral T-cell lymphomas rarely present as ascites; this case demonstrates the value of effusion cytology in making this diagnosis.
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PMID:Peripheral T-cell lymphoma presenting as ascites: a case report and review of the literature. 1035 13