Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019214 (hepatosplenomegaly)
 4,408 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From July, 1974 to February, 1978, we managed 12 infants with listeriosis. This infection presented in two distinct forms: an early-onset type (nine patients), often representing a congenital infection following maternal illness, and a late-onset type in which the patient presented with meningitis (three patients). Of our nine infants with early-onset disease, three died, three developed permanent sequelae, and only three were normal at follow-up. Appropriate early management in the perinatal period may improve the outlook in this condition. Affected infants were often premature and had pneumonia, rash, and hepatosplenomegaly at birth. Prenatal clues to the diagnosis included maternal fever, abdominal pains, and leukocytosis with meconium staining of the preterm amniotic fluid. Examination of gastric aspirate at birth showed gram-positive coccobacilli. Antibiotic therapy should be started prenatally and continue for three weeks after birth to prevent recurrences of the late-onset type. This late-onset disease presented as meningitis after the second week of life and responded well to antibiotics. Our three patients recovered without sequelae.
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PMID:Perinatal listeriosis--a review of twelve patients. 43 5

During the years 1988-1997 listeriosis was detected in nine (2.4%) of 373 perished hares, in one of these cases calicivirus was additionally found. The listeriosis occurred sporadically. Granulomatous hepatosplenomegaly was the main lesion observed. Pregnancy is an important predisposing factor for the outbreak of listeriosis: six of the nine cases were hares post abortum or with retention of macerated foetuses in utero.--Six Listeria strains were serotyped and all belonged to serovar 1/2a.
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PMID:[Listeriosis in the European brown hare in northern Germany]. 1020 7