Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

23 cases of T-lineage acute lymphoblastic leukemia (TALL) were identified by multiple monoclonal antibodies. TALL was characterized by a younger age of the patients (average age 28 years), strong male preponderance (M:F, 4.8: 1), mediastinal mass (19%), higher leucocyte count (71.4%), hepatomegaly (76.2%) and splenomegaly (90.5%). Of 19 cases of TALL who were subclassified according to the criteria for subclassification of TALL proposed by Reinherz, 10 cases expressed a surface antigen pattern consistent with the early thymocyte stage of TALL development, 8 cases were of common thymocyte stage and 1 case was of mature thymocyte stage. The phenotypes of TALL cells appear to be considerably heterogeneous. 12 of 18 patients who received chemotherapy had achieved complete remission (67%).
Zhonghua Nei Ke Za Zhi 1992 Jan
PMID:[T-lineage acute lymphoblastic leukemia. Report of 23 cases]. 139 10

Among 203 patients with high altitude erythrocythemia (HAE), 89% had various kinds of alimentary canal symptoms, while these were present only in 31% of a control group (P less than 0.01). 49% of the HAE group had stomach, while only 8% of the control group had it. Endoscopic examination revealed 44% of the HAE group had peptic ulcer, being much higher than 6% of the control group. The ratio of gastric to duodenal ulcer in the HAE group was 2 to 1. The HAE patients had higher values of ALT, total bilirubin, LDH activity, LDH1 and LDHs, but lower values of AKP, LDH2, LDH4 and gamma-GT than the controls. The difference was, however, of no statistical significance. B mode ultrasonography showed that the incidence of hepatomegaly and splenomegaly was 24% and 11% respectively in the HAE group, while it was only 4% and 2% in the control group. HAE patients usually had symptoms of digestive system two years after the onset and the incidence at that time was 67%. With the extended course of the disease, the incidence gradually came down. The mechanism of digestive system impairment in HAE was probed and it was shown that treatment of digestive system impairment would promote the healing of HAE.
Zhonghua Nei Ke Za Zhi 1991 Aug
PMID:[Impairment of the digestive system in high altitude erythrocythemia]. 179 46

The immunophenotype of leukemicblasts from 111 patients with T-ALL or T-NHL were further examined by using a panel of standardized McAbs of CD nomenclature to human leukocyte differentiation antigens. Four major subsets of T-ALL were defined: pre T-ALL, immature T-ALL (I), common T-ALL (II) and mature T-ALL (III), with the percentages 20.7%, 20.7%, 20.7% and 37.0% respectively. In addition there was a case with M-T acute hybrid leukemia. Some of the clinical features of the patients with T-ALL and T-NHL were compared. It was found that male predominance, older age, higher leukocyte count, lower platelet level, relative higher hemoglobin level and increased incidence of extramedullary involvement, including hepatomegaly, splenomegaly and lymphadenopathy were alike for all subsets of T-ALL cases. However, the average white cell level and incidence of lymphadenopathy in the pre T-ALL subset significantly differed from those in other subsets. The correlation of immunophenotype with morphologic characterization was also discussed in this paper.
Zhonghua Nei Ke Za Zhi 1991 Jan
PMID:[Correlation of immunophenotype with clinical features in T-cell acute lymphoblastic leukemia]. 203 95

The clinical characteristics of hepatic tuberculosis in 52 cases diagnosed pathologically were analyzed. Fever, abdominal pain and hepatomegaly were the major clinical manifestations; they were present in 96.2%, 42.3% and 88.5% of the patients respectively. The fever had no consistent pattern and the abdominal pain was usually localized to the right hypochondrium and not related to overwork. Hypergrammaglobulinaemia, elevated alkaline phosphatase level and increased ESR were noted in most of the patients (76.9%, 75.0%, 76.5% respectively). 62.5% of the 52 patients was diagnosed by percutaneous liver biopsy. Since there is no consistent clinical pattern in patients with hepatic tuberculosis, the diagnosis should be considered in patients with unexplained fever associated especially with hepatomegaly or hepatosplenomegaly, elevated alkaline phosphatase level, hypergrammaglobulinaemia and increased ESR, Liver biopsy is the most valuable method to confirm the diagnosis of hepatic tuberculosis.
Zhonghua Nei Ke Za Zhi 1995 Jan
PMID:[Clinical characteristics of hepatic tuberculosis]. 760 Aug 75

The clinical features of 6 cases with severe veno-occlusive disease (SVOD) in 43 patients who received hemopoetic stem cell transplantation (HSCT) in our institute from May 1983 to March 1994 were reported. The incidence of SVOD was 14% of the 43 patients, and 7.9% of those received autologous bone marrow transplantation (ABMT), SVOD occurred within 3 weeks after HSCT in all the 6 cases and was manifested by painful hepatomegaly, jaundice, hyperbilirubinemia, increase of serum liver enzyme level and ascites. Although supportive and symptomatic treatment including steroids were given, all patients died of progressive multiorgan failure within 4 weeks after HSCT. It is suggested that SVOD of the liver is a major and often lethal complication of HSCT and prophylaxis of this disorder with anticoagulant and antiplatelet agents is essential in clinical HSCT.
Zhonghua Nei Ke Za Zhi 1995 Jun
PMID:[Hepatic veno-occlusive disease after hemopoetic stem cell transplantation]. 858 82

Systemic lupus erythematosus is an uncommon disease in men. The clinical and pathological features and prognosis in 50 male patients with lupus nephritis (LN) and 50 age-matched female patients with LN were analysed. The age at which the disease began and the diagnosis was made was generally older in the male. The incidence of LN was higher in the male than in female (P < 0.01). The incidence of types IV and V LN was more common in the male than in female. Type II LN was not found in male patients. Proteinuria over 3.5g/24h and renal failure were more common in the male than in female (P < 0.05). The three most common clinical manifestations in male patients were irregular fever, skin rashes and painful joints. Rashes, hepatomegaly and neuropsychiatric dysfunction were more common in the male than in female. The patients were followed up one to twelve years. The rate of recovery and improvement was lower, but that of relapse and mortality higher in the male than in female.
Zhonghua Nei Ke Za Zhi 1995 Dec
PMID:[Lupus nephritis in male adults, an analysis of the clinical and pathological features]. 873 62

A case of Armillifer agkistrodontis disease was reported. Armillifer agkistrodontis is a species of the Armillifer genus of the Linguatulida order and parasitizing agkistrodon acutus. According to literature reviewed, there has been no report of this disease caused by infection of Armillifer agkistrodontis in human being prior to this case all over the world. The clinical features of this disease are long-term high fever, abdominal pain, diarrhea, mild anemia, hepatosplenomegaly, eosinophilia in bone marrow and blood and multiple polyps in the whole colon. The pathologic features of the liver biopsy was degeneration and necrosis of hepatocytes and obvious infiltration of eosinophils. This disease should be differentiated from several other diseases which can also cause hepatomegaly, long-term high fever, abdominal pain and diarrhea. Mebendazole is an effective medication for this disease, but the long term effect of praziquantel is not certain. It is necessary to make further studies on the epidemiology, etiology, pathology, natural history, clinical features, diagnosis, differential diagnosis and therapy of this disease.
Zhonghua Nei Ke Za Zhi 1996 Nov
PMID:[Armillifer agkistrodontis disease: report of case]. 959 42

To know the clinical characteristics and the prognostic factors of hyperleukocytic acute leukemia, we reviewed 244 patients with acute leukemia associated with hyperleukocytosis. Restrospective analysis and control study were used. Hyperleukocytosis occured in 8.5% of patients with acute leukemia. Hyperleukocytosis in ALL was more common than that in AML. Among AML with hyperleukocytosis, M5 subtype was the most. Hepatomegaly, splenomegaly, lymphadenopathy, DIC and CNSL were more frequent in hyperleukocytosis group. The complete remission rate was 41.4% for patients with hyperleukocytosis versus 54.2% for patients with non-hyperleukocytosis. The early mortality rate was significantly increased in hyperleukocytic patients (23.8%) as compared to the nonhyperleukocytic group (11.1%). Intracranial hemorrhage was the main cause of early death. The high risk factors of early death were: hemoglobin < or = 40 g/L, blood platelet < or = 30 x 10(9)/L, DIC, infection, CNSL at presentation. Acute leukemia with hyperleukocytosis has poor prognosis. Especially, acute myeloid leukemia with hyperleukocytosis must be taken seriously because of high early mortality rate.
Zhonghua Nei Ke Za Zhi 1997 Aug
PMID:[244 patients with hyperleukocytic acute leukemia. Shanghai Leukemia Cooperation Group]. 1043 59