Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was done on 45 patients with bilharzial hepatosplenomegaly and active bilharzial infection classified into 3 groups. The first group was given oral oxamniquine 2nd group was given oral praziquantel, the third group was left as control. It was proved that praziquantel gave a remarkable decrease in portal vein diameter and regression of the size of enlarged liver and spleen but oxaminiquine had no significant effect on the portal vein diameter and liver profile.
J Egypt Soc Parasitol 1989 Dec
PMID:Ultrasonographic profile of the liver and caliber of portal vein after oral antibilharzial drugs. 250 26

On June 11, 1986, a 70-year-old man was introduced to our hospital because of an elevated AFP and hepatomegaly. He was diagnosed as having an HCC in the left medial segment and a transcatheter arterial embolization (TAE) was able to reduce his AFP level. In December, 1986, repeated tarry stool was noted, and he was readmitted to hospital on January, 28, 1987, because of severe anemia. An ordinary X-ray revealed an abnormal gas shadow in the right upper abdomen. A subsequent endoscopic examination showed a tumoral mass protruding into the duodenal lumen through a duodenal perforation. After death an autopsy revealed that the perforation was due to the expansive growth of the tumoral mass to the duodenum.
Gan No Rinsho 1989 Dec
PMID:[A case of hepatocellular carcinoma (HCC) with bleeding due to duodenal perforation by the tumor]. 255 30

A 3.5 year old girl presented with a history of high fever, rigors, and mild cough for 1 week. Physical examination revealed normal chest findings but gross hepatomegaly was detected. Liver function tests were abnormal and indicated biliary obstruction. Ultrasonography revealed a distended gall-bladder with increased wall thickness up to 0.6 cm. The diagnosis of primary Epstein-Barr viral infection was eventually made by specific serological study. The patient's fever subsided 2 weeks later and her liver function tests returned to normal 1 month later. Abdominal ultrasonography at this time was normal.
Aust Paediatr J 1989 Dec
PMID:Persistent high fever and gall-bladder wall thickening in a child with primary Epstein-Barr viral infection. 255 86

An effusive-constrictive pericarditis confined to the epicardium is extremely rare in childhood. We report case of a 7-year-old boy with such a condition. During an annual school health examination, he was found to have low voltage activities on electrocardiogram. On admission, physical examination showed markedly distended abdomen due to ascites and hepatomegaly. Two-dimensional echocardiography revealed small ventricular cavities, extremely dilated inferior vena-cava, and a moderate amount of pericardial fluids. Pericardial and epicardial thickening were also suspected. Retrospectively, epicardial thickening was suspected on computed tomogram as well. Cardiac catheterization showed a typical diastolic dip and plateau pattern on the right ventricular pressure tracing, and deep x and y descents on that of the right atrium, suggesting that not pericardial effusion, but pericardial thickening mainly contributed to the cardiac dysfunction. Pericardiocentesis did not improve the clinical symptoms and high central venous pressure. On thoracotomy, we unexpectedly found intact pericardium and fibrotic epicardium covering the whole heart, so epicardiectomy was performed. Despite the fact that most of the fibrotic epicardium was removed, there were no immediate responses such as decrease in central venous pressure within the first 5 days after the surgery. Furthermore, it was not until two months later that all symptoms and hemodynamic parameters returned to normal levels. There have been several case reports of isolated epicardial constriction associated with pericardial effusion in English literature. However, we are unaware of such a report n Japanese. We concluded that it is important to evaluate the hemodynamics before and after pericardiocentesis, and to detect peri-and/or epicardial thickening by serial echocardiography and CT scan.(ABSTRACT TRUNCATED AT 250 WORDS)
Kokyu To Junkan 1989 Dec
PMID:[A case of effusive-constrictive epicarditis found by electrocardiogram at a school health examination]. 261 11

The clinical characteristics of 100 patients diagnosed of congestive hepatomegaly have been reviewed in order to analyze some of the clinical and analytical parameters. The protocol for the study consisted of ten variables: sex, age, quality and size of the hepatomegaly, presence of hepatojugular reflux, jugular engorgement, ankle edema, abdominal ultrasonography, laboratory data and any other pertinent exploration. The mean age of the patients was 69 (31%). 65% of the cases had ankle edema. Prothrombin time was abnormal in 12% of the total series and in 27.9% of those with abnormal laboratory data. The most common ECG finding was atrial fibrillation (26%). The second most common was complete bundle block (21%).
Rev Esp Enferm Apar Dig 1989 Dec
PMID:[Clinical aspects of stasis hepatomegaly]. 263 34

Search for livelihood makes many people move from kala azar endemic areas to metropolitans like Delhi from where indigenous cases have not been reported. During 1986-1989, 211 laboratory confirmed kala azar cases were detected in Delhi. Of these 202 (95.73 per cent) were from Bihar and remaining nine (4.27 per cent) belonged to Uttar Pradesh. Younger age groups were affected more and maximum cases (54.02 per cent) were in the age group of 5-15 years. Male:female ratio was 2:1. Fever (100 per cent) along with mass in abdomen (99.05 per cent) were the major presenting complaints. Splenomegaly was seen in all the patients whereas hepatomegaly was a feature in 184 (87.20 per cent) cases. Response to sodium antimony gluconate (SAG) was variable and number of injections administered reached upto 80 in some (23) cases. All 37 patients responded to pentamidine after two full courses of SAG failed to bring about any clinical and parasitological cure.
J Commun Dis 1989 Dec
PMID:Clinicoepidemiological profile of kala azar patients in Delhi. 263 73

Seventy eight patients with diffuse hepatic lesions were selected for this study. They were classified after liver biopsy histopathologically into four groups. 45 patients with pure bilharzial hepatomegaly (group 1). 12 patients with mixed bilharzial hepatosplenomegaly with hepatitis (group 2). 16 patients with chronic active hepatitis and cirrhosis (group 3) and 5 patients with extrahepatic cholestasis (group 4). Ultrasonography of gall bladder was done for all patients. Group 3 patients showed the highest incidence of gall stones (29.4%) as compared to other groups (P less than 0.05).
J Egypt Soc Parasitol 1989 Dec
PMID:Pattern of gall bladder sonography in chronic liver diseases. 267 Nov 76

Mediterranean Spotted Fever is a disease caused by Rickettsia conorii. It is endemic to the Mediterranean area, where, for the last few years, the number of cases has increased, possibly due, in part, to climatic factors. The main clinical aspects of a prospective series of 246 cases diagnosed from 1983 to 1988 are presented. The most characteristic manifestations were fever, exanthema and tache noire. Other frequent manifestations were headache, myalgia and arthralgia, and with lesser frequency, hepatomegaly, splenomegaly, gastrointestinal symptoms and conjunctivitis. Notable analytical changes are the rise of hepatic and muscular enzymes in a large number of patients. In some cases we have found signs of myositis in muscular biopsy. The evolution of our patients was usually favorable though serious and even deadly forms of the disease have been described. One of the factors that seems to greatly influence the appearance of these forms is delay in the initiation of effective treatment.
Eur J Epidemiol 1989 Dec
PMID:New trends in Mediterranean spotted fever. 269 Dec 73

An unusual case of Campylobacter fetus subspecies fetus bacteremia was presented. A twenty four year old male was admitted to our hospital due to abdominal pain, general malaise, diarrhea, high fever, and hemoptysis. He was alcoholic and fond of eating raw liver. He had a history of partial gastrectomy and disturbance of pancreatic function. He showed pulmonary empyema, pleuritis, thrombophlebitis of lower legs, jaundice, hepatomegaly, diarrhea, pneumothorax, and low T3 low T4 syndrome. C. fetus subsp. fetus was detected from the venus blood and pleural effusion on admission. He was successfully treated by gentamicin, chloramphenicol, and minocycline. This is the fourth case of C. fetus subsp. fetus bacteremia in the Japanese literature. This microanerophilic gram negative curved bacillus has been increasingly associated with human disease and relapsing in nature, so protracted antimicrobial therapy was recommended.
Kansenshogaku Zasshi 1989 Dec
PMID:[A case report of Campylobacter fetus subspecies fetus bacteremia]. 269 82

It is important to define clinical signs that can be used to identify children who have a high risk of dying from pneumonia so that these children can be given more intensive therapy. We prospectively studied 748 children in Papua New Guinea who had severe pneumonia, as defined by the World Health Organization. There was a very high mortality in children with a prolonged illness, severe roentgenogram changes, cyanosis, leukocytosis, hepatomegaly or inability to feed, and there was a trend toward a higher mortality in children with grunting or severe chest indrawing. Afebrile malnourished children had a particularly high mortality, but afebrile children had an increased mortality only if they were malnourished, and malnourished children had an increased mortality only if they were afebrile. Mortality was not increased in very young children or in children with tachypnea or tachycardia. The World Health Organization has suggested that most children with pneumonia in developing countries can be treated with penicillin but has recommended that children who are cyanotic or too sick to feed be treated with chloramphenicol because of their high risk of dying; our findings confirm that children who are cyanotic or too sick to feed have a very high risk of dying from pneumonia.
Pediatr Infect Dis J 1989 Dec
PMID:Clinical signs that predict death in children with severe pneumonia. 269 26


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