Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Caroli's disease is a rare congenital anomaly of the liver. Since new diagnostic techniques for the evaluation of hepatic disease have been introduced, the number of reported cases of Caroli's disease has been gradually increasing. This report describes the case of a 13 year old girl with nausea, vomiting, fever and hepatomegaly. The diagnosis of Caroli's disease was established by ultrasonography and CT scan. The complications and management are discussed. The important points in management are to relieve symptoms and to conduct regular examinations by ultrasonography for the early detection of hepatobiliary carcinoma.
Acta Paediatr Jpn 1991 Dec
PMID:Caroli's disease: scintigraphic and radiographic findings. 180 49

Evaluation of the liver and biliary tract is one of the principal applications of abdominal ultrasonography in small animals. Indications include hepatomegaly, mass in the area of the liver, suspected hepatic metastasis, jaundice, ascites, suspected diaphragmatic rupture, and weight loss. Ultrasonography is a valuable method for evaluating the internal structure of the liver and biliary tract. Certain functional assessments also may be made, for example, measurement of induced gallbladder emptying after cholecystokinin injection. Limitations of ultrasonography include lack of specificity for focal or multifocal hepatic lesions and insensitivity for certain infiltrative diseases, such as lymphosarcoma. These limitations contribute to diagnostic difficulties, which are adequately addressed only by biopsy. The technique of ultrasound-guided biopsy is described briefly.
Probl Vet Med 1991 Dec
PMID:Ultrasonography of the liver and biliary tract. 180 69

In a prospective study, 38 consecutive cases of primary liver cell carcinoma were seen over one year (1988) at the liver unit of the University College Hospital, Nigeria. An analysis of the chest X-ray findings was made. Normal chest X-rays were found in 23.7% of cases. Abnormal findings included elevated diaphragm (63.2%), pulmonary metastases (18.4%), and pleural effusion (18.4%), perhaps the highest ever so reported. It may be concluded that, in a middle-aged man with a hard irregular hepatomegaly, the findings of the triad of elevated diaphragm, pulmonary metastasis and pleural effusion on chest X-ray should make one very suspicious of liver cancer. The differential diagnoses of these radiological findings are briefly discussed.
Br J Clin Pract 1990 Dec
PMID:The chest radiograph in primary liver cell carcinoma. 196 10

We report four patients with amebic liver abscess diagnosed in our hospital between January 1985 and January 1990. Mean patient age was 40 years. All patients had previously travelled to an endemic area. Fever, weight loss, right-upper-quadrant pain and hepatomegaly were the most frequent clinical manifestation. Two patients had a history of diarrhea. Diagnosis was made by epidemiology, clinical manifestation, ultrasonic scanning and computerized tomography and serologic test. Two patients received metronidazole exclusively and two patients required percutaneous catheter drainage under ultrasound guidance.
Rev Esp Enferm Dig 1990 Dec
PMID:[Amebic liver abscess: presentation of 4 cases]. 209 4

Chronic granulocytic leukaemia (CGL) is the commonest leukaemia among adults in India. Case records of 183 CGL patients diagnosed between 1975 and 1985 were reviewed. The median age at diagnosis was 40.5 years. Most patients presented with weakness, fullness in the left upper abdomen and fever. Splenomegaly and hepatomegaly were present in 90% and 48% respectively. Patients were treated with oral, intermittent busulphan with monitoring of total leucocyte count. Overall, 87 patients expired, including 63 (72%) due to blast crisis. The median survival was 33 months from diagnosis and 44 months from the onset of symptoms.
J Assoc Physicians India 1990 Dec
PMID:Chronic granulocytic leukaemia. A study of 160 cases. 162 26

A 69-year-old male, who had been found (during a routine roentgenogram of the chest at an annual check-up) to have cardiomegaly, had been asymptomatic until 63 years of age, when DOE and swelling of the legs appeared. He visited our hospital because these symptoms has become more severe. Physical examination revealed JVD, third heart sound and a grade 3 holosystolic murmur, hepatomegaly and edema in the lower legs. His ECG showed atrial fibrillation. His chest X-P showed marked cardiomegaly and rt pleural effusion. His echocardiography and MRI revealed a marked enlargement of the right atrium and a slight enlargement of the right ventricle. The latter also showed persistent left superior vena cava. The cardiac catheterization, angiocardiography and intracavitary electrocardiography revealed no organic cardiac disease which induced enlargement of the right atrium. The idiopathic enlargement of the right atrium is a rare disease. Patients suffering from this disease are asymptomatic in most cases. We reported the idiopathic enlargement of the right atrium with persistent left superior vena cava in this paper.
Kokyu To Junkan 1990 Dec
PMID:[Idiopathic enlargement of the right atrium with persistent superior vena cava]. 214 15

From 1984 to 1989, 52 cases with Budd-Chiari syndrome were surgically treated at the PUMC Hospital. Among them there were 31 cases of membranous obstruction of the inferior vena cava (MOVC, 59.6%). There were 24 males and 7 females, ase ranging from 24 to 36 years. Diagnosis was confirmed by inferior venocavagraphy. According to Sugiura's Classification, there were type Ia and Ib in 26 cases, and type II in 5. Edema and varicosity on both legs, the chest, the abdomen, and the back were found in 93.5% (29/31), and hepatomegaly, splenomegaly, and large amount of ascites were found in 61.3% (19/31), 64.5% (20/31), and 54.8% (17/31), respectively. Transcardiac membranotomy was performed in 27 cases, and the remaining 4 cases were treated by percutaneous transluminal angioplasty using balloon catheters both without operative mortality. Four to sixty months' follow-up in 29 cases revealed satisfactory results. The authors belief that membranotomy can be successfully performed in cases of MOVC when the stricture is located well above the level of T-9th vertebra, and with a length of less than 2 cm.
Zhonghua Wai Ke Za Zhi 1990 Dec
PMID:[Diagnosis and treatment of membraneous obstruction of the inferior vena cava]. 215 Jul 99

The laparoscopic findings in 13 patients with liver fasciolasis are described. Diagnosis was made in three cases in base of the presence of ova Fasciola Hepatica in the patient's faeces and in 10 cases, because they fulfilled the following conditions: ingestion of fresh watercress, eosinophilic count exceeding 30%, positive serologic tests, eosinophilic granulomas with Charcot-Leyden crystals in liver biopsy and good response to treatment with dihidroemetine or bithionol. Nine cases (68.2%) showed hepatomegaly. In 12 of 13 (92.3%) lesions suggestive of hepatic distomatosis were found. Hepatic nodules of different sizes and shapes could be seen in 10 patients (76.9%), Glisson capsule was involved in five cases (38.4%) and peritoneum in three (23%). The latter was always affected with the liver but, on the other hand, liver capsule was found affected alone in two cases. In our experience, laparoscopy with liver biopsy is an important method for diagnosis of abdominal fasciolasis.
Rev Esp Enferm Dig 1990 Dec
PMID:[Laparoscopic findings in liver fascioliasis. Study of 13 cases]. 215 Nov 16

Identical male twin infants who in 1987 presented with hepatoblastoma at the age of 7 months are reported. Twin B was admitted for investigation due to enlarged liver and spleen. He was found to have an inoperable hepatoblastoma of fetal type and was treated with chemotherapy and local irradiation. However, 7 months after the chemotherapy the tumor recurred. The asymptomatic twin A was examined because of the known familial cases, and he proved to have an identical tumor. He was successfully radically operated on and 2 years after the chemotherapy is still doing well with no evidence of tumor. As the mother and the maternal grandmother had polyps in the colon, quite probably the hepatoblastomas of the twins were associated with familial adenomatous polyposis.
Cancer 1990 Dec 01
PMID:Simultaneous hepatoblastoma in identical male twins. 217 73

Immunotherapy with interleukin (IL)-2 possesses great potential in the treatment of immune-mediated diseases and cancers. However, only a few reports on a small number of children have appeared in the literature. From March 1988 to March 1989, 11 children and adolescents were treated with IL-2. They included 1 patient with hepatocellular carcinoma, 1 with hepatoblastoma, 6 with childhood atopic dermatitis, and 3 with juvenile rheumatoid arthritis. The dosages ranged from 10,000 to 50,000 U/kg every 8 hours by intravenous drip. The following side effects were observed: anorexia, fever, and chillness (100%), general malaise (82%), irritability (64%), diarrhea (100%), nausea and vomiting (73%), weight gain (82%), edema (82%), abdominal distension (73%), oliguria (82%), cough (91%), dyspnea (27%), pleural effusion (40%), hypotension (82%), skin eruption (82%), oral ulcer (18%), enlarged liver (73%) liver function abnormalities (82%), renal function impairment (36%), electrolyte imbalance (73%), anemia (91%), thrombocytopenia (54%), leukopenia (18%), and eosinophilia (73%). Immunologically, numbers of natural killer cells were increased and natural killer and lymphokine-activated killer cell activities were augmented after IL-2 treatment. There was a tendency for serum levels of IL-2 and receptor IL-2 to decrease, especially in patients with atopic eczema. Ten patients (91%) completed one course (9 to 12 days) of therapy, and the remaining patient interrupted the treatment because of intolerable adverse effects. Clinically, complete remission for 3 months was obtained in 1 juvenile rheumatoid arthritis patient, transient improvement (2 to 6 weeks) in all atopic dermatitis patients, minor response in the hepatoblastoma patient, and no response in the patient with hepatocellular carcinoma.
Pediatrics 1990 Dec
PMID:Interleukin-2 immunotherapy in children. 217 36


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