Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six hundred and fifty seven hospitalized patients under five in Child Health Department Hospital Tembakau Deli Medan, from January 1988 until December 1988 had been investigated retrospectively. Severe PCM are found 12 (1.8%), consisting of 7 (58.3%) boys and 5 (41.7%) girls. Most cases were found at the age of 1-2 years (33.3%). Marasmus were found in 5 cases (41.7%), Marasmic kwashiorkor in 4 (54%), while Kwashiorkor in 3 cases (25%). Clinical features of the patients are as follow: hepatomegaly 7 (58.3%), anorexia 6 (50%), old man face 5 (41.7%), subcutaneous fat decrease 5 (41.7%), thinsparse easily pick hairs 5 (41.7%), muscle hypotrophy 5 (41.7%), edema of the lower extremity 4 (33.3%), crazy pavement dermatosis 2 (16.7%). All patients were hospitalized combined with other diseases as chronic diarrhea 6 (50%), bronchopneumonia 5 (41.7%) and ascariasis 4 (33.3%). Mortality in 1 patient.
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PMID:Clinical features of severe malnutrition at the pediatric ward of Tembakau Deli Hospital, Medan. 207 60

From February, 1981 to May, 2001, 63 children under 15 y old (ages 2 - 15 y, median = 8 y, mean +/- 1 SD = 8 +/- 3 y) presenting 70 episodes of Paracoccidioidomycosis were admitted. The main clinical manifestations and laboratory features observed upon admission were: lymph node enlargement (87.1%), fever (75.7%), weakness (48.6%), pallor (41.4%), hepatomegaly (40%), splenomegaly (35.7%), anemia (90%), hypergammaglobulinemia (88.5%), eosinophilia (75.5%) and hypoalbuminemia (72.5%). Moderate to severe malnutrition was detected in 35.7% of the episodes (Gomez's criterion). Radiographic and technetium studies showed bone lesions in 20 of the episodes, most of them being multiple lytic lesions, involving both long (70%) and plain bones (30%). First line treatment consisted of an association of sulfametoxazole-trimethoprin, which was used, exclusively, in 50 episodes. Follow-up of hemoglobin levels, number of eosinophils in the peripheral blood, albumin and gammaglobulin serum levels revealed significant sequential improvement one and six months after hospital admission, being quite useful to evaluate treatment effectiveness. Six patients died (9.3%) and four developed sequelae (6.3%). In conclusion, the juvenile and disseminated forms can be observed in about 70% of the episodes of PCM occurring in children younger than 15 y old, most of them presenting with a febrile lymphoproliferative syndrome associated to anemia, eosinophilia and hypergammaglobulinemia.
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PMID:Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome. 1528 12