Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 34-week preterm infant was evaluated for direct hyperbilirubinemia and hepatomegaly at 2 weeks of age. Dopamine had been used in the management of hypotension in the early neonatal period; the drug had been inappropriately infused into the right branch of the portal vein. Ultrasonography of the abdomen at 2 weeks showed mild hepatomegaly and a hypoechoic area in the right lobe of the liver posteriorly. Follow-up ultrasonogram at 3 months showed the liver to be of normal size and echogenicity. Hyperbilirubinemia was resolved by 3 1/2 weeks. No other problems were specifically related to the hepatic injury.
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PMID:Hepatic injury: a possible complication of dopamine infusion through an inappropriately placed umbilical vein catheter. 639 25

The hepatorenal syndrome (HRS) is a unique form of acute renal failure with entirely normal renal histology in advanced liver disease. Its diagnosis is made by exclusion of all causes of renal failure and by all the five major criteria as set by the International Ascites Club. The presence of hepatomegaly, poor nutritional status, and oesophageal varices at endoscopy are associated with a high risk of HRS. The liver tests, the Child-Pugh score, are of no value in prediction of its occurrence. Contraction of the effective blood volume, which may lead to renal hypoperfusion with preferential renal cortical ischaemia, is proposed pathogenesis of the condition. Because understanding of the pathogenesis of HRS is incomplete, therapy is supportive only. Optimal fluid management is vital as there is almost invariably a reduction in effective arterial blood volume. Dopamine, frusemide and haemofiltration may be helpful in management of fluid overload but do not affect renal function. TIPS has been used successfully in small series of patients. The vasopressin analog also has been used with early excellent response. The treatment of HRS has been discouraging and the only proven cure for HRS is liver transplantation at this point of time.
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PMID:Hepatorenal syndrome: pathophysiology and treatment. 1224 Aug 52