Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A fire disaster following LPG tanker explosion occurred at Chala bypass, Kannur, Kerala, India on August 27, 2012. The three chambered tanker with total 16tonnes (162.57 quintal) LPG collided with a road divider and exploded thrice. A total of 41 people became victims during first blast; out of which 20 died in various hospitals. Five people remained inside the house after first blast and escaped unhurt from the zone of accident before second blast. All the victims were transferred to various hospitals; of these, six were transferred to the burns unit of the Kasturba Hospital, Manipal (320km from Chala). Five (5/6) were transferred within 1-5 days at our burns unit suffered 31-72% total body surface area (TBSA) burn, none had external injuries. One (1/6) was transferred on 20th day as a follow up case of 15% TBSA burn with 4% residual raw area and diabetes mellitus. Except one, all were managed conservatively using Limited access dressings (LAD; Negative Pressure Wound Therapy). One of the patient wound bed prepared under LAD and on 41 post burn day underwent split skin grafting under LAD. Out of the six patients admitted at the burns unit, two (2/6) admitted patients expired (one due to inhalation injury and another due to sepsis with multiple organ failure). One survivor (1/4) developed sepsis related liver dysfunction with hepatomegaly but recovered well. The total hospital stay of survivors at the burns unit varied from 8 to 60 days (mean hospital stay 36.5 days). All the victims who developed psychological symptoms were treated by psychiatrists and counselled before discharge. Three of survivors developed psychological symptoms. Two of them (2/3) developed mixed anxiety-depression disorder (ICD 10 code F41.8) and one of these two showed grief reaction too (ICD 10 code F43.23). One victim (1/3) developed non-organic insomnia (ICD 10 code F51.0) and responded to counselling. The article describes the incident, mechanism of the incident, injuries sustained, author, explanations on pattern of burn and suggestions in relation to future safety measures.
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PMID:Fire disaster following LPG tanker explosion at Chala in Kannur (Kerala, India): August 27, 2012. 2363 22

Significant deficiencies in coenzyme Q(10) have been documented in a wide variety of diseases in both animal and human studies. Known predominately for its functions as an antioxidant and membrane stabilizer, coenzyme Q(10) supplementation also has been demonstrated to effectively lower blood pressure, decrease total cholesterol and low-density lipoprotein cholesterol, increase levels of high-density lipoprotein cholesterol, and decrease symptoms of dyspnea, peripheral edema, enlarged liver, and insomnia. The majority of clinical work with coenzyme Q(10) in the past two decades has focused on its role in heart disease. While usually found in high concentrations in heart muscle cells, both serum and tissue levels of coenzyme Q(10) are often lower in people with congestive heart failure. The severity of coenzyme Q(10) deficiency is directly related to the severity of heart failure. Correcting deficits in coenzyme Q(10) in heart failure patients can mitigate or reverse myocardial dysfunction and necrosis. The addition of coenzyme Q(10) to conventional treatments in congestive heart failure patients has been shown to improve quality of life and decrease hospitalization rates. In an effort to improve outcomes in patients supplemented with coenzyme Q(10), various delivery mechanisms to improve the bioavailability of coenzyme Q(10) are currently under investigation.
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PMID:Coenzyme q(10) supplementation in the treatment of heart disease. 2396 19