Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Evaluation of the liver and biliary tract is one of the principal applications of abdominal ultrasonography in small animals. Indications include hepatomegaly, mass in the area of the liver, suspected hepatic metastasis, jaundice, ascites, suspected diaphragmatic rupture, and weight loss. Ultrasonography is a valuable method for evaluating the internal structure of the liver and biliary tract. Certain functional assessments also may be made, for example, measurement of induced gallbladder emptying after cholecystokinin injection. Limitations of ultrasonography include lack of specificity for focal or multifocal hepatic lesions and insensitivity for certain infiltrative diseases, such as lymphosarcoma. These limitations contribute to diagnostic difficulties, which are adequately addressed only by biopsy. The technique of ultrasound-guided biopsy is described briefly.
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PMID:Ultrasonography of the liver and biliary tract. 180 69

A Doberman with jaundice, hepatomegaly and cranial abdominal pain had evidence of centrilobular necrosis on liver biopsy. Therapy with fluids, ampicillin and rest resulted in recovery. A Collie hit by a car developed traumatic hepatopathy and myopathy. The animal recovered with rest as the only treatment. A mongrel with hepatic lymphosarcoma benefited from chemotherapy for 5 months before euthanasia was necessary. A cat became lethargic and anorectic 9 days after an oral dose of piperazine. Liver biopsy revealed fatty change, vacuolation and mononuclear infiltration. Supportive care with amoxicillin, fluids and a high caloric intake resulted in recovery. Laparotomy in a jaundiced, anorectic cat revealed an obstructed common bile duct. Cholecystoduodenostomy and supportive care resulted in recovery. A vomiting, lethargic, jaundiced cat had evidence of chronic cholangitis on liver biopsy. The animal recovered after treatment with amoxicillin, fluids, prednisolone and forced feeding.
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PMID:Management of liver disease in dogs and cats. 654 4

Thoracic and abdominal radiographs from 100 dogs with lymphosarcoma were reviewed to determine the type and frequency of radiographic abnormalities associated with the disease. Sternal lymphadenopathy was the most frequent (60%) thoracic radiographic abnormality. Hepatomegaly (47%), splenomegaly (55%), and sublumbar lymphadenopathy (49.5%) were the most frequent abdominal radiographic abnormalities; these were most often seen in combination. A single radiographic abnormality or combination of abnormalities was not observed frequently enough to suggest that a diagnosis could be made only on the basis of radiographic findings.
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PMID:Thoracic and abdominal radiographic abnormalities in the multicentric form of lymphosarcoma in dogs. 689 27

Lymphosarcoma is described in a wild juvenile harbor seal (Phoca vitulina richardii). Gross lesions included hepatomegaly, splenomegaly and lymphadenopathy. Neoplastic lymphoid cells were observed histologically in lung, kidney, liver, spleen, adrenals, bone marrow and visceral and peripheral lymph nodes.
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PMID:Lymphosarcoma in a harbor seal (Phoca vitulina richardii). 689 10

Granulomatous hepatitis (GH) is an uncommon histopathologic diagnosis in dogs. On the basis of clinical reports, fungal infections appear to be the most common cause of GH in dogs, but many other potential causes have been identified. The medical records and histopathologic findings for 9 dogs with GH were reviewed to identify additional specific causes of GH in dogs. Diseases associated with GH included intestinal lymphangiectasia (n = 2), lymphosarcoma (n = 1), histiocytosis (n = 1), dirofilariasis (n = 1), and histoplasmosis (n = 1). In 1 dog, no other disease process was identified. Of the remaining 2 dogs, 1 had concurrent granulomatous pneumonitis of unknown cause, and the other had periportal hepatitis and temporal muscle wasting. All 9 dogs with GH had clinical evidence of liver disease, such as hepatomegaly, icterus, and ascites, or had high serum alkaline phosphatase and alanine aminotransferase activity. Because of the wide variety of potential causes of GH in dogs, an accurate diagnosis should be sought so that appropriate treatment can be chosen and an accurate prognosis given.
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PMID:Granulomatous hepatitis in dogs: nine cases (1987-1990). 840 37

A 6-mo-old male Savannah monitor lizard (Varanus exanthematicus) was presented for lethargy and anorexia of 7 days duration. Physical examination revealed a slightly raised subcutaneous mass (1 cm diameter) in the left scapular area. Fine-needle aspiration cytology of the mass revealed a population of immature, pleomorphic lymphoid cells consistent with lymphosarcoma. A hemogram indicated marked leukocytosis (465,000 cells/microl) characterized by extreme lymphocytosis and many circulating lymphoid blast cells. The lizard was euthanized at the owner's request. Necropsy revealed severe hepatomegaly and multiple raised, ulcerated mural masses in the gastrointestinal tract. There were many raised, poorly demarcated tan foci in all the parenchymal organs. Histopathologic examination confirmed infiltration of all parenchymal organs by neoplastic lymphoid cells. Transmission electron microscopic examination failed to identify viruses within the neoplastic cells. A literature review revealed few reports of squamate leukemia and lymphosarcoma and none in Savannah monitor lizards.
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PMID:Lymphosarcoma with leukemic blood profile in a Savannah monitor lizard (Varanus exanthematicus). 1036 59