Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019209 (hepatomegaly)
 5,798 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was made of the clinical picture, certain laboratory and immunological findings in pseudotuberculosis patients with involved joints in the presence of opisthorchiasis invasion. The patients suffering from pseudotuberculosis and chronic opisthorchiasis frequently demonstrated icteric sclera, erythema nodosum, skin itch, tenderness in the right hypochondrium, hepatomegaly, liquid stool, leukopenia, eosinophilia, hyperbilirubinemia, activation of aminotransferases. Later they showed the diagnostic titers of the indirect hemagglutination test, an increase in disease duration, delayed disappearance of the main clinical symptoms. As compared to patients suffering from arthritides without invasion, the patients with associated pseudotuberculous arthritides and opisthorchiasis demonstrated a higher activity of the inflammatory process in the joints, an increase of the duration and number of polyarthritis relapses, alterations in the immunological indicators (a stable reduction of the T lymphocyte and T helper count as well as a rise of the IgM level during late convalescence).
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PMID:[The characteristics of pseudotuberculosis with joint involvement in the presence of chronic opisthorchiasis]. 181 61

Yersinia pseudotuberculosis infection was diagnosed in 12 children on the basis of recovery of the organism from stool cultures and a 4-fold or greater titer change in agglutinating antibody. Eight of the 12 Yersinia isolates were recovered from stool cultures only after cold enrichment. Clinical findings in 50% or more of patients were fever, rash, diarrhea, desquamation, strawberry tongue, vomiting, red and cracked lips, abdominal pain, arthralgias, hepatomegaly and conjunctivitis. The patients' clinical manifestations and courses of illness resembled those of Izumi fever, an illness that occurs epidemically in Japan. Additionally the finding in two children fulfilled the strict criteria for Kawasaki syndrome, and signs in the other 10 children were consistent with that diagnosis.
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PMID:Yersinia pseudotuberculosis infection in children, resembling Izumi fever and Kawasaki syndrome. 634 44