Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 4484
Mol 4098
HCC 2985
alpha-fetoprotein 2637
p53 2197
insulin 1950
interferon 1821
surface antigen 1345
caspase-3 1273
albumin 1195
AFP 1126
Bcl-2 987
cytokine 982
AKT 928
catenin 884
endoplasmic reticulum 850
mTOR 735
IFN 714
PLC 680
PI3K 665
ATP 657
p21 651
vascular endothelial growth factor 644
ERK 641
glycoprotein 553
IL-6 553
E-cadherin 543
alanine aminotransferase 524
MRI 520
tumor necrosis factor 518
cyclin D1 513
TNM 509
NMR 509
MAPK 505
tyrosine kinase 469
histone 469
STAT3 460
TNF 456
collagen 439
p38 432
Alpha-fetoprotein 429
prothrombin 422
polypeptide 415
UTR 409
GSH 395
serum albumin 391
cytochrome c 384
ERK1 379
ras 378
cytochrome P450 377
JNK 373
CD8 365
lectin 364
interleukin-6 363
aspartate aminotransferase 346
caspase-9 342
core protein 338
alkaline phosphatase 333
microsomal 332
cytochrome 330
c-myc 327
proliferating cell nuclear antigen 326
VEGF 321
fused 318
matrix metalloproteinase 314
PARP 312
aryl hydrocarbon receptor 311
proteasome 311
ubiquitin 305
vimentin 297
ROS 294
hepatocyte growth factor 292
caspase-8 289
c-Myc 287
CD4 286
gut 278
transferrin 275
xenobiotic 273
epidermal growth factor receptor 273
MEK 272
CYP1A1 271
annexin V 269
Fas 269
TAT 269
PEG 266
cage 263
insulin receptor 259
MMP-9 257
She 250
AMP 248
phosphatase 243
epidermal growth factor 243
catalase 243
superoxide dismutase 243
beta-catenin 241
fibronectin 241
glutathione S-transferase 241
p27 233
c-Jun 233
CD133 231
ferritin 227
MMP-2 227
SDS 225
lipopolysaccharide 224
colon carcinoma 224
lactate dehydrogenase 222
survivin 222
Ah receptor 221
PTEN 220
EGFR 219
Sp1 218
p65 216
carcinoembryonic antigen 216
fibrinogen 214
Ki-67 214
P-glycoprotein 214
extracellular signal-regulated kinase 214
kit 212
lymphoid 210
AP-1 209
insulin-like growth factor 200
glucocorticoid receptor 198
AST 197
reductase 196
erythropoietin 194
nuclear receptor 192
thymidine kinase 191
TACE 190
cytokeratin 19 186
STAT 184
interferon-alpha 184
histone deacetylase 181
thymus 181
signal transducer and activator of transcription 3 180
protein kinase B 179
Gen 178
chemokine 178
CCK 176
phosphatidylinositol 3-kinase 175
LC3 175
threonine 173
TNF-alpha 172
membrane-bound 171
A-I 171
ATPase 171
IL-10 170
apolipoprotein 170
HEP 169
EBP 169
osteosarcoma 169
estrogen receptor 169
hemochromatosis 169
cyclin E 168
phosphoenolpyruvate carboxykinase 167
glypican 166
cyclin 165
Cytokine 164
NAD 163
p16 163
GST 161
more...
Disease
hepatocellular carcinoma 71386
tumor 22326
cancer 21368
cirrhosis 11620
liver cancer 7544
hepatitis B 6923
Hepatocellular carcinoma 6346
hepatitis C 4994
liver cancer 4548
chronic hepatitis 4199
liver disease 4017
carcinoma 3232
HCC 2985
carcinogenesis 2821
tumor growth 2745
hepatitis 2526
tumorigenesis 2258
metastases 2053
chronic liver disease 1867
tumor progression 1609
virus infection 1395
breast cancer 1152
fatty liver 1130
adenocarcinoma 1107
viral hepatitis 1077
diabetes 1039
liver fibrosis 1026
obesity 1015
Nonalcoholic fatty liver 709
lung cancer 670
melanoma 655
colorectal cancer 640
leukemia 627
gastric cancer 617
arterial embolization 590
metabolic syndrome 523
adenoma 517
MCF 507
hepatoblastoma 480
portal hypertension 466
alcoholic fatty liver 458
HIV 452
colon cancer 447
acute hepatitis 435
lymphoma 418
Chronic hepatitis B 418
chronic active hepatitis 413
renal cell carcinoma 408
type 2 diabetes 397
GSH 395
liver metastases 388
prostate cancer 386
infectious diseases 373
primary tumor 371
sarcoma 364
pancreatic cancer 340
squamous cell carcinoma 319
lung carcinoma 302
hemangioma 296
alcoholic cirrhosis 280
hypertension 278
Infection 267
Chronic hepatitis C 266
hemochromatosis 253
tumor angiogenesis 249
glioma 245
alcohol abuse 245
iron overload 244
dysplasia 243
aggressiveness 243
immunodeficiency 239
Cirrhosis 238
NS3 235
SDS 225
esophageal varices 222
neuroblastoma 222
anemia 216
ovarian cancer 211
cervical cancer 211
ischemia 209
cardiovascular disease 208
primary biliary cirrhosis 207
Chronic infection 203
cholestasis 201
solid tumor 199
viremia 194
lung metastases 191
osteosarcoma 187
retinoblastoma 184
varices 177
atherosclerosis 170
HEP 169
alcoholism 165
hepatic encephalopathy 165
B-cell lymphoma 165
non-small cell lung cancer 163
multiple myeloma 162
thrombocytopenia 159
glioblastoma 157
West 149
Hodgkin's disease 147
fibrosarcoma 145
AS1 144
herpes simplex 142
obstructive jaundice 141
AIDS 141
EMT 141
hepatitis D 139
cholangitis 136
sepsis 135
SCID 133
tumor initiation 131
chronic persistent hepatitis 130
hepatitis A 129
bladder cancer 127
esophageal cancer 125
sepsis 123
neoplastic transformation 122
hyperlipidemia 121
cold 117
depression 117
esophageal cancer 114
DDP 114
B virus infection 113
cytomegalovirus 112
dyslipidemia 112
alcoholic hepatitis 110
angiosarcoma 110
Epstein 107
acute myeloid leukemia 107
encephalopathy 107
liver abscess 107
epithelial ovarian cancer 106
residual disease 106
Budd-Chiari syndrome 106
renal failure 102
Best 99
Cholangiocarcinoma 99
non-Hodgkin's lymphoma 98
hypoglycemia 98
bone metastases 97
primary sclerosing cholangitis 97
hepatic adenoma 96
Blocking 95
celiac disease 94
tuberculosis 93
Cholangiocarcinoma 89
Wilson's disease 89
hyperglycemia 88
HGF 88
WT1 87
mammary tumor 87
renal disease 85
malaria 85
tyrosinemia 85
malnutrition 84
gallstones 84
hereditary hemochromatosis 83
hepatic neoplasm 83
aggression 82
more...
Symptom
pain 331
abdominal pain 316
hepatomegaly 199
starvation 183
fatigue 170
diarrhea 164
nausea 113
anorexia 105
vomiting 98
weakness 88
cachexia 86
anesthesia 83
dyspnea 75
collapse 66
splenomegaly 63
overweight 63
exhaustion 58
headache 54
Ill 47
epigastric pain 46
nausea and vomiting 45
cough 34
right upper quadrant pain 32
discomfort 32
discomfort 32
seizures 31
abdominal discomfort 30
back pain 29
chest pain 25
lethargy 22
hepatosplenomegaly 20
erythema 19
analgesia 17
abdominal fullness 17
acute abdomen 16
bone pain 16
respiratory distress 15
decreased appetite 15
shortness of breath 15
asthenia 15
hemoptysis 14
myalgia 13
leg edema 13
HSA 13
arthralgia 13
constipation 13
hypothermia 12
acidity 12
numbness 12
hypoproteinemia 12
ataxia 11
acute abdominal pain 11
exertional dyspnea 11
chills 10
flank pain 10
flushing 10
regurgitation 9
agitation 9
syncope 9
tremor 9
sleepiness 8
low back pain 8
ophthalmoplegia 8
fever of unknown origin 8
paresthesia 8
cancer pain 8
leg pain 7
dizziness 7
stigma 6
Spots 6
acute stress 6
cyanosis 6
hoarseness 5
functional recovery 5
bloating 5
pallor 5
Wind 5
hyperoxia 5
cerebellar ataxia 5
paraparesis 4
Scratch 4
angina 4
emaciation 4
dark urine 4
oliguria 4
spasm 4
hemiplegia 4
thinning 4
vertigo 4
eye discharge 3
DNA marker 3
neck pain 3
intestinal bleeding 3
dysarthria 3
Decreased activity 3
eds 3
dysuria 3
consciousness disturbance 3
spasticity 3
night sweats 3
productive cough 3
No adverse effect 3
Postoperative pain 3
paresis 3
abnormal breathing 3
shoulder pain 3
colic 3
autodigestion 3
arm pain 3
insomnia 3
hip pain 2
hypocapnia 2
orthopnea 2
Fluctuation 2
hypercapnia 2
Catch 2
apathy 2
tingling 2
clubbing 2
dystonia 2
polydipsia 2
incoordination 2
alexithymia 2
facial pain 2
rigors 2
persistent cough 2
pedal edema 2
dry skin 2
tonic-clonic seizure 2
chronic cough 2
Tenderness 2
stomach pain 2
masculinization 2
tense 2
syncopal episodes 1
wheezing 1
POA 1
neurological disability 1
hunger 1
Sedation 1
blurred vision 1
hot flushes 1
urinary frequency 1
photophobia 1
general problem 1
forgetfulness 1
lassitude 1
Hudson 1
right lower quadrant pain 1
breath holding 1
Welt 1
CSR 1
mastalgia 1
breakthrough pain 1
jaw pain 1
intention tremor 1
skin damage 1
otalgia 1
peri-menopausal 1
localized edema 1
more...
Drug
Sorafenib 818
Lipiodol 398
lysine 355
ROS 294
Adriamycin 165
Gel 151
IL-2 148
DNase I 145
Monit 137
Cardiovasc 134
IFN-gamma 133
Portal 116
vitamin E 112
ROC 106
Ethanol 97
Albumin 86
GEO 84
ascorbate 83
NADH 71
ADM 68
MAP 67
ABC 60
Gelfoam 57
Dermatol 54
caffeine 53
Glutathione 51
CSF 49
lactose 49
Arsenic trioxide 42
IFN-beta 42
Asn 40
TAT 38
Retinoic acid 37
CTX 36
EE2 36
Sonazoid 35
Vitamin K 34
G418 33
Meth 32
Nexavar 32
Biopolymers 31
Entecavir 31
PCB 31
Levovist 31
MRC 31
Entecavir 31
Heme 30
ADR 29
Paraffin 28
Mutagen 27
Kenyan 27
uPA 27
ENT 27
Leaf 26
citric acid 25
CoCl2 24
CoCl2 24
Serum albumin 23
CAM 23
ICI 23
Taxol 22
Glycyrrhiza 22
PMEA 21
Indomethacin 20
Bayer 20
Gelatin 20
Vitamin A 19
AGG 19
Bevacizumab 19
Vitamin E 19
Gefitinib 19
IL-11 19
CTX 18
CTX 18
HCH 18
niacin 17
CCL 17
CTA 17
ATV 17
ALA 17
Glucagon 17
PMPA 17
Nephron 16
CPT-11 16
EPI 16
CTC 15
Fraction 15
Galactose 15
Oxaliplatin 15
THF 14
PTC 14
Tenofovir 14
Emodin 14
CTC 14
Indocyanine green 14
Emodin 14
Troglitazone 13
CaCl2 13
CaCl2 13
Parkin 13
L-tyrosine 13
-deoxyadenosine 13
EPA 13
Parkin 13
CaCl2 13
Fructose 13
Erlotinib 12
Vitamin K2 12
ETS 12
AZT 12
Spectrum 12
Bortezomib 12
TAC 12
ZnO 12
Ginseng 12
Pravastatin 12
AZT 12
Activin 12
nitroglycerin 11
Growth hormone 11
NVP 11
Ketoconazole 11
Fluorescein 11
G-CSF 11
Growth hormone 11
Etoposide 11
VCR 10
NH3 10
ampicillin 10
AMC 10
Dial 10
Everolimus 10
balanced salt solution 10
pyridoxal phosphate 10
Cremophor EL 10
Lovastatin 9
Estrogens 9
RFP 9
PTH 9
Omeprazole 9
Bifidobacterium 9
Dakar 9
Pronase 9
Prednisolone 9
Acacia 9
Simvastatin 9
VCR 8
BH4 8
Tacrolimus 8
Leucovorin 8
NAG 8
Dasatinib 8
ZnCl2 8
Isoniazid 8
Ranitidine 8
TiO2 8
CDP 8
Angiotensin II 8
ZnCl2 8
Alliance 8
more...
Enzyme
mitogen-activated protein kinase 1601
ERK 1495
luciferase 1375
caspase-3 1013
alanine aminotransferase 1004
protein kinase 839
focal adhesion kinase 570
aspartate aminotransferase 556
catalase 389
glutathione S-transferase 381
MEK 360
gamma-glutamyl transpeptidase 356
reverse transcriptase 354
PARP 353
protein kinase C 341
alkaline phosphatase 334
proteasome 315
caspase-9 291
superoxide dismutase 290
AMP-activated protein kinase 281
tyrosine aminotransferase 253
lactate dehydrogenase 237
chloramphenicol acetyltransferase 225
caspase-8 224
P-glycoprotein 216
NQO1 214
RNA polymerase 210
ATPase 204
trypsin 203
AST 196
phosphoenolpyruvate carboxykinase 193
thymidine kinase 191
TACE 190
AMPK 184
peroxidase 181
phosphatidylinositol 3-kinase 177
cdc2 175
phosphoenolpyruvate carboxykinase 174
RNase 168
phosphoenolpyruvate carboxykinase 162
RNase 159
calcineurin 155
ACS 150
AMPK 147
CYP3A4 146
GSK 145
glucose-6-phosphatase 143
glutathione peroxidase 141
DNA polymerase 139
phosphoinositide 3-kinase 126
ornithine decarboxylase 116
urokinase-type plasminogen activator 116
APC 108
hexokinase 108
collagenase 108
neuraminidase 104
glutamine synthetase 103
aldehyde dehydrogenase 100
aldehyde dehydrogenase 98
aldehyde dehydrogenase 95
aldehyde dehydrogenase 95
aldehyde dehydrogenase 95
alcohol dehydrogenase 92
aryl hydrocarbon hydroxylase 92
beta-galactosidase 92
thrombin 89
transcriptase 87
arginase 84
DNA methyltransferase 81
topoisomerase 80
pyruvate kinase 79
endonuclease 76
topoisomerase 73
phospholipase C 72
IKK 69
DNase 67
acetylcholinesterase 66
ceruloplasmin 66
phosphodiesterase 65
MMP 61
lipase 61
thymidylate synthase 60
glyceraldehyde-3-phosphate dehydrogenase 59
glucose-6-phosphate dehydrogenase 58
CD10 58
cholinesterase 57
tissue plasminogen activator 57
heme oxygenase 56
demethylase 54
adenylate cyclase 54
NADPH oxidase 54
granzyme B 53
NADPH oxidase 52
UDP-glucuronosyltransferase 51
cathepsin D 51
glutathione reductase 50
ribonuclease 50
ribonuclease 50
caspase-1 50
phospholipase A2 49
protein phosphatase 2A 48
firefly luciferase 48
ACE 47
soluble epoxide hydrolase 47
complex I 47
MAP 47
fumarylacetoacetate hydrolase 46
CD13 45
glyceraldehyde-3-phosphate dehydrogenase 45
cathepsin B 44
dihydrofolate reductase 44
acetyl-CoA carboxylase 44
methionine adenosyltransferase 44
plasmin 43
succinate dehydrogenase 43
acid phosphatase 43
thromboplastin 43
endoglycosidase H 42
CPR 42
CYP7A1 41
thioredoxin reductase 40
phenylalanine hydroxylase 40
PDK1 39
glucokinase 39
TAT 38
matrix metalloproteinase 2 37
lipoprotein lipase 37
renin 37
ATP synthase 37
glyceraldehyde-3-phosphate dehydrogenase 37
chymotrypsin 37
acyl-CoA oxidase 36
sialyltransferase 36
pyruvate dehydrogenase 36
glyceraldehyde-3-phosphate dehydrogenase 35
glyceraldehyde-3-phosphate dehydrogenase 35
sialyltransferase 35
cholesterol acyltransferase 35
sialyltransferase 35
MDR 34
CPT 34
diaphorase 34
aldolase 34
adenosine deaminase 33
adenosine deaminase 33
5'-nucleotidase 32
NO synthase 32
gamma-glutamylcysteine synthetase 31
prolyl hydroxylase 30
beta-glucuronidase 29
argininosuccinate synthetase 29
3-hydroxy-3-methylglutaryl-CoA reductase 28
pyruvate dehydrogenase 28
papain 28
xanthine oxidase 28
transpeptidase 28
pyruvate dehydrogenase 28
IMP dehydrogenase 27
PMT 27
NOS 27
more...
Compound
DNA 7730
Dec 4864
Clin 3572
oxygen 1807
glucose 1344
MTT 1298
ethanol 1246
water 925
sodium 900
iron 868
tyrosine 739
methionine 664
calcium 661
ATP 657
phosphate 566
acetate 546
galactose 523
TNM 509
sulfate 496
serine 461
TNF 456
cysteine 449
PEG 447
lysine 438
GSH 429
GSH 429
Insulin 404
aflatoxin B1 403
arginine 391
bromide 365
cAMP 356
copper 330
zinc 320
PEG 318
hydrogen 312
iodine 307
leucine 304
Adriamycin 298
His 287
pyrene 281
retinoic acid 281
threonine 278
urea 277
alanine 273
AMP 269
MEK 262
5-FU 252
MDA 241
SDS 236
nitric oxide 233
Pac 218
glutamine 203
NAD 192
TACE 190
nitrogen 181
salt 180
DEN 171
HEP 169
ADR 169
N-acetylcysteine 168
ADP 167
NAD 163
H2O2 159
uridine 158
Phe 158
methanol 158
selenium 155
CAT 151
ACS 149
CAT 149
CAT 149
ACS 146
ADP 145
ADP 145
Asp 137
DTPA 136
pyrimidine 136
silver 136
TOF 136
pyrimidine 135
adenosylmethionine 133
ammonium 132
cadmium 130
DDP 130
CO2 128
NH2 127
aldehyde 126
glutamate 125
GlcNAc 124
DEAE 122
tryptophan 122
CoA 118
NADPH 117
creatinine 116
TCDD 115
NADPH 115
GTP 112
manganese 109
Curcumin 108
proline 105
CCl4 104
Dexamethasone 104
dUTP 103
tryptophan 102
ethyl acetate 101
COS 100
tryptophan 100
tryptophan 100
glycerol 100
Vimentin 100
ammonia 99
acetic acid 98
DMSO 98
Ile 94
anthracene 94
Estrogen 91
ADP-ribose 91
TEM 91
MMC 89
alcohol dehydrogenase 85
palmitic acid 84
potassium 84
retinol 83
nicotinamide 82
diacetate 82
Gly 81
asparagine 80
Mg2+ 80
vinyl 77
acridine 76
MTS 75
THP 75
ASA 74
aldehyde 73
EDTA 73
valine 73
THP 73
EDTA 72
3TC 71
8-OHdG 71
phenol 71
NADH 71
vitamin D 70
ornithine 68
ornithine 68
ornithine 68
ornithine 68
ornithine 68
pyridine 68
hyaluronic acid 67
chloroform 67
HCl 66
PEI 66
cobalt 66
Triton X-100 66
PEI 66
acetaldehyde 65
Optimal 64
TCA 64
Metformin 63
more...