Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies.
Materials & methods:
Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method.
Results:
Seven prognosis-related autophagy genes were more significantly related to the prognosis of
hepatocellular carcinoma
(
HCC
). Functional enrichment analysis demonstrated that these genes were mainly enriched in the autophagy pathway.
BIRC5, HSPB8
and
TMEM74
exhibited significant prognostic value for
HCC
. Besides, the risk score and
BIRC5
have significant significance with clinicopathological significance of
HCC
.
Conclusion:
The research has identified a number of prognosis-related autophagy genes that associated with the survival and clinical stage of
HCC
. In addition, the prognostic model can be used to calculate the patient's risk score and these prognosis-related autophagy genes might serve as therapeutic targets.
...
PMID:Construction prognosis model based on autophagy-related gene signatures in hepatocellular carcinoma. 3302 90
