Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatocellular carcinoma
(
HCC
) is one of the most common malignancies globally, and is frequently associated with a poor prognosis. 5-methylcytosine (m
5
C) is a common epigenetic modification with many critical roles in eukaryotes. However, the expression and functional roles of m
5
C regulators are largely unknown. In this study, we utilized The Cancer Genome Atlas (TCGA) to determine the expression, gene signatures, and prognostic values of m
5
C-related genes. We confirmed that the frequency of mutation events of m
5
C regulatory genes was high in
HCC
(35/363). Dysregulation of m
5
C-related genes was also associated with a higher
HCC
stage. Moreover, a strong relationship was found between the expression of m
5
C regulatory genes and
HCC
patient survival. High expression of
NSUN4
and
ALYREF
correlated significantly with survival outcome. We developed a two-gene signature of m
5
C regulators with
HCC
prognostic value based on the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression models. Gene set enrichment analysis (GSEA) results indicated that high expression of
NSUN4
was associated with methylation and demethylation processes. Meanwhile, high expression of
ALYREF
was clearly related to cell cycle regulation and mitosis. In conclusion, our results revealed that m
5
C-related genes play an essential role in tumor progression in
HCC
. Further detection of m
5
C methylation could provide a novel method for
HCC
targeted therapy.
...
PMID:Role of m
5
C-related regulatory genes in the diagnosis and prognosis of hepatocellular carcinoma. 3226 23
