Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that
RNA-binding motif protein 43
(
RBM43
) is significantly downregulated in human tumors, and its low expression is correlated with poor prognosis in patients with
HCC
. Overexpression of
RBM43
suppressed cell proliferation in culture and resulted in the growth arrest of tumor xenografts, whereas downregulating
RBM43
played an opposite role. We have also demonstrated that overexpression or knockdown of
RBM43
affects the cell-cycle progression of liver cancer cells. Mechanistically,
RBM43
directly associated with the 3'UTR of Cyclin B1 mRNA and regulated its expression. Moreover, loss of Rbm43 in mice promoted liver carcinogenesis and
HCC
development after diethylnitrosamine (DEN)-carbon tetrachloride (CCl
4
) treatment. Taken together, our data indicate that
RBM43
is a tumor suppressor that controls the cell cycle through modulation of Cyclin B1 expression, providing evidence that
RBM43
is particularly important in
HCC
.
...
PMID:RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression. 3263 20
