Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
This study aimed to identify long noncoding RNAs (lncRNAs) with potential to be prognostic biomarkers of
hepatocellular carcinoma
(
HCC
) by analyzing copy number alterations (CNAs).
Methods:
RNA Sequencing data of 369
HCC
patients was downloaded from The Cancer Genome Atlas database and analyzed with a series of systematic bioinformatics methods.
Results:
LncRNA-CNA association analysis revealed that many lncRNAs were located in sites frequently amplified or deleted. Three upregulated lncRNAs (LINC00689, SNHG20 and MAFG-AS1) with copy amplification and one downregulated lncRNA
TMEM220
-AS1 with copy deletion were associated with poor prognosis of
HCC
.
Conclusion:
This study reveals that differentially expressed lncRNAs correlate with CNAs in
HCC
. Moreover, the differentially expressed lncRNAs and their copy amplification/deletions could be promising prognostic biomarkers of
HCC
.
...
PMID:Identification of prognostic biomarkers of hepatocellular carcinoma via long noncoding RNA expression and copy number alterations. 3277 64
