Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. In this study, we found that
ubiquitin associated protein 2
(
UBAP2
) was significantly downregulated in
hepatocellular carcinoma
(
HCC
) tissues compared with adjacent normal tissues. Furthermore, higher expression of
UBAP2
in cancer tissues was correlated with good prognosis in
HCC
patients. Knockdown of
UBAP2
significantly enhanced the invasion and proliferation of
HCC
cells in vitro and promoted tumor growth in vivo, while enforced expression of
UBAP2
impaired the aggressive ability and tumor growth of
HCC
cells. Mechanistically,
UBAP2
formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited
HCC
progression. Collectively,
UBAP2
appears as a novel marker for predicting prognosis and a therapeutic target for
HCC
.
...
PMID:UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2. 2712 Oct 50
