Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study aimed to illustrate the association of the expression of
ubiquitin-conjugating enzyme E2A
(
UBE2A
) with the clinicopathological parameters and prognosis in
hepatocellular carcinoma
(
HCC
). The expression levels of
UBE2A
mRNA and protein in a total of 276
HCC
tissues and six liver cell lines was detected by fluorescent quantitative polymerase chain reaction, western blotting and immunohistochemistry. Statistical analysis was also performed to assess the association of the expression of
UBE2A
with the clinicopathological parameters and prognosis by the GraphPad Prism and SPSS version 21.0 software.
UBE2A
mRNA and protein were highly expressed in
HCC
tissues compared with those in the adjacent normal tissue. Immunohistochemical analysis revealed that
UBE2A
protein was more strongly stained in the 276 paraffin-embedded
HCC
tissues as compared with the 63 adjacent normal tissue. Statistical analysis also demonstrated that
UBE2A
expression was significantly associated with histological differentiation, TNM stage and vascular invasion of
HCC
(P<0.05). Notably,
HCC
patients with a high expression of
UBE2A
had a shorter survival time as compared with those with a low expression of
UBE2A
. There results suggested that
UBE2A
may be involved in the pathogenesis of
HCC
and may serve as an important prognostic marker. Further exploration of the involvement of
UBE2A
in
HCC
development may provide novel therapeutic targets.
...
PMID:High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma. 2972 49
