Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatocellular carcinoma
(
HCC
) is one of the leading causes of cancer death worldwide. Endoplasmic reticulum stress (ERS) is generally activated in
HCC
and is important for the sensitivity of
HCC
to anticancer drugs. ERS-dependent autophagy is a crucial mechanism affecting the sensitivity of
HCC
to anticancer drugs, but the mechanism by which ERS regulates autophagy is not well understood.
Zinc finger protein 263
(
ZNF263
) is a transcription factor member of the zinc finger family. However, its functional role in
HCC
remains to be studied. In the current study, we investigated the role of
ZNF263
in regulating ERS-induced chemoresistance in
HCC
and its possible mechanism. We found that
ZNF263
was the most significant ERS-specific super-enhancer bounding transcriptional factor and was up-regulated in
HCC
patients and cell lines. Further,
ZNF263
expression correlated with ERS, clinical stage and shorter survival in
HCC
patients.
ZNF263
knockdown by RNA interference results in decreased proliferation, apoptosis resistance, and chemoresistance. Further study showed that
ZNF263
increased chemoresistance by activating ERS-related autophagy. In conclusion, our study highlights
ZNF263
as a functional ERS-related tumor activator and indicates it as a potential target for
HCC
therapy.
...
PMID:A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy. 3289 66
