Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Overexpression of
transmembrane 4 L six family member 5
(
TM4SF5
), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of
TM4SF5
in migration, invasion, and tumor metastasis remain unknown. Using in vitro
hepatocarcinoma
cells that ectopically or endogenously express
TM4SF5
and in vivo mouse systems, roles of
TM4SF5
in metastatic potentials were examined. We found that
TM4SF5
expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of
TM4SF5
with its shRNA blocked the effects. Altogether,
TM4SF5
-mediated migration and invasion suggest that
TM4SF5
may be therapeutically targeted to deal with
TM4SF5
-mediated hepatocellular cancers.
...
PMID:Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis. 2050 53
Hepatocellular carcinoma
(
HCC
) is a major cause of cancer-related mortality. Recent studies have indicated that
transmembrane 4 L six family member 5
(
TM4SF5
) serves a vital role in tumor progression and metastasis in human cell lines and mouse models. However, little is known about the association between
TM4SF5
expression and clinicopathological factors. The aim of the current study was to investigate this association and evaluate overall survival (OS) of patients. Immunohistochemistry and clinical record analysis revealed that
TM4SF5
expression was significantly downregulated in
HCC
tissues. In addition,
TM4SF5
expression was significantly associated with tumor size, vascular invasion, tumor differentiation, and tumor-node-metastasis stage. The survival analysis also demonstrated that low
TM4SF5
expression resulted in shorter OS. In conclusion, the association between
TM4SF5
expression and clinicopathologic factors was established, and prognostic significance of
TM4SF5
as a potential biomarker was evaluated using human
HCC
formalin-fixed paraffin-embedded tissue samples. The results of the present study demonstrated that low
TM4SF5
expression was associated with tumor malignant progression and may be a good prognostic biomarker for OS in
HCC
.
...
PMID:Clinicopathological significance of TM4SF5 expression in human hepatocellular carcinoma tissues. 3118 34
