Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Accumulating researches identify microRNA-26a (miR-26a) as a tumor suppressor in
hepatocellular carcinoma
(
HCC
).
F-box protein 11
(
FBXO11
), a predicted target gene of miR-26a, is an E3 ubiquitin ligase and a type II methyltransferase, and functions as a key regulator of tumor initiation and progression. This study was aimed to investigate the regulatory role of miR-26a in
FBXO11
expression and explored the clinical significance as well as functional role of
FBXO11
in
HCC
. The expression levels of miR-26a were prominently downregulated in
HCC
tissues compared to matched tumor-adjacent tissues. MiR-26a inversely regulated
FBXO11
abundance in
HCC
cells. Hereby, miR-26a could directly target 3'UTR of
FBXO11
mRNA to suppress its expression. Gene Expression Omnibus (GEO) database (GSE54236 and GSE45436) and our data demonstrated that the expression of
FBXO11
was up-regulated in
HCC
tissues. The level of
FBXO11
mRNA was inversely correlated with miR-26a expression in
HCC
specimens. High
FBXO11
expression was positively correlated with large tumor size, venous infiltration and advanced tumor stage of
HCC
patients. Clinical prognostic analysis illustrated that high
FBXO11
expression predicted a poor survival of
HCC
patients. In vitro,
FBXO11
knockdown inhibited cell proliferation, colony formation, migration and invasion of
HCC
cells. Additionally, miR-26a overexpression showed a consistent effect with
FBXO11
knockdown on these malignant behaviors of
HCC
cells. Notably,
FBXO11
restoration reversed the inhibitory effect of miR-26a on
HCC
cell proliferation, colony formation, migration and invasion. In summary, these results indicated that miR-26a regulation of
FBXO11
exhibited an oncogenic role in
HCC
. Inhibition of
FBXO11
might serve as a therapeutic target for
HCC
.
...
PMID:The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. 2951 11
