Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long non-coding RNAs (lncRNAs) play important roles in a variety of tumours; however, their biological function and clinical significance in
hepatocellular carcinoma
(
HCC
) are still unclear. In the present study, the clinical significance, biological function and regulatory mechanisms of lncRNA
DCST1
-AS1 in
HCC
were investigated. Differential lncRNAs in
HCC
were identified based on The Cancer Genome Atlas (TCGA) database. The biological function and mechanism of
DCST1
-AS1 were studied
in vitro
and
in vivo
LncRNA
DCST1
-AS1 was highly expressed in
HCC
tissues, and the high expression of
DCST1
-AS1 was significantly correlated with larger tumours and shorter survival time. Moreover,
DCST1
-AS1 knockout significantly inhibited proliferation, promoted apoptosis and cycle arrest of
HCC
cells, and inhibited tumour growth
in vivo
According to functional analysis,
DCST1
-AS1 competitively bound miR-1254, thus blocking the silencing effect of miR-1254 on the target gene Fas apoptosis inhibitor 2 (
FAIM2
). A novel lncRNA
DCST1
-AS1 that functions as an oncogene in
HCC
was discovered.
DCST1
-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of
HCC
cells. This research provides new therapeutic targets for
HCC
.
...
PMID:LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma. 3061 87
