Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
GTP binding protein overexpressed in skeletal muscle
(
Gem
) is a Ras-related protein whose expression is induced in several cell types upon activation by extracellular stimuli. To investigate the potential roles of
Gem
in
hepatocellular carcinoma
(
HCC
), expression of
Gem
was examined in human
HCC
samples. Western blot analysis showed that compared with primary human hepatocytes and adjacent noncancerous tissue, significant down-regulation of
Gem
was found in
HCC
cells and tumor tissues. In addition, immunohistochemical analysis of
Gem
expression was investigated in 108 specimens of
HCC
tissues. Clinicopathological data were collected to analyze the association with
Gem
expression. Expression of
Gem
was significantly negatively correlated with histological grade (P=0.001), tumor size (P=0.020), and vascular invasion (P=0.005), and
Gem
was also negatively correlated with proliferation marker Ki-67 (P<0.01). More importantly, the Kaplan-Meier survival curves analysis revealed that low expression of
Gem
was associated with poor prognosis in
HCC
patients. Univariate analysis showed that
Gem
expression was associated with poor prognosis (P=0.006). Multivariate analysis indicated that
Gem
expression was an independent prognostic marker for
HCC
(P=0.007). Finally, serum starvation and release experiments showed that
Gem
expression was negatively related with cell proliferation. In the conclusion, our results suggested that down regulation of
Gem
expression was involved in the pathogenesis of
hepatocellular carcinoma
, and it might be a favorable independent prognostic parameter for
HCC
.
...
PMID:Identification of Gem as a new candidate prognostic marker in hepatocellular carcinoma. 2515 51
