Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatocellular carcinoma
(
HCC
) is one of the most lethal cancers worldwide. The poor survival may be due to a high proportions of tumor recurrence and metastasis.
Kinesin family member C1
(
KIFC1
) is highly expressed in a variety of neoplasms and is a potential marker for non-small cell lung cancer or ovarian adenocarcinoma metastasis. Nevertheless, the role of
KIFC1
in
HCC
metastasis remains obscure. We investigated this in the present study using
HCC
cell lines and clinical specimens. Our results indicated that increased levels of
KIFC1
were associated with poor prognosis and metastasis in
HCC
. In addition,
KIFC1
induced epithelial-to-mesenchymal transition (EMT) and
HCC
metastasis both in vitro and in vivo. This tumorigenic effect depended on gankyrin; inhibiting gankyrin activity reversed EMT via activation of protein kinase B (AKT)/Twist family BHLH transcription factor 1 (AKT/TWIST1). We also found that
KIFC1
was directly regulated by the microRNA miR-532-3p, whose downregulation was associated with metastatic progression in
HCC
. These results denote that a decrease in miR-532-3p levels results in increased
KIFC1
expression in
HCC
, leading to metastasis via activation of the gankyrin/AKT/TWIST1 signaling pathway.
...
PMID:KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. 3011 76
Hepatocellular carcinoma
(
HCC
) is a common type of malignant tumor worldwide with a high mortality rate. In the past 20 years, the morbidity rate of
HCC
has increased. Progress has been made in the clinical diagnosis and therapy for
HCC
. However, due to the high heterogeneity and metastasis targeted therapy for
HCC
exhibits great promise, and novel therapeutic targets for
HCC
are urgently required.
Kinesin family member C1
(
KIFC1
) is a member of the kinesin superfamily of proteins. Previous studies have indicated a potential association between
KIFC1
and cancer progression. However, the potential role of
KIFC1
in the development of
HCC
remains unclear. The present study aimed to explore the function of
KIFC1
in
HCC
. Immunohistochemical (IHC) assays were performed to explore the KIF15 expression levels in 74 samples of
HCC
and corresponding non-tumor tissues. The potential association between KIF15 expression levels and clinical features was analyzed, and the effects of KIF15 on cell proliferation of
HCC
were detected by colony formation and MTT assays. In addition, the proliferation-related proteins Ki67 and PCNA were detected by western blotting. The possible effects of KIF15 on tumor growth were measured in mice. The results demonstrated that a high expression level of
KIFC1
was associated with poor prognosis of
HCC
. Further results indicated that
KIFC1
promoted cell proliferation of
HCC
in vitro
. In addition, knockdown of
KIFC1
suppressed tumor formation and growth in mice. Therefore, these results provide a potential therapeutic target for the treatment of
HCC
.
...
PMID:KIFC1 promotes the proliferation of hepatocellular carcinoma
in vitro
and
in vivo
. 3178 47
