Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BACKGROUND
Angiogenic factor with G patch and FHA domains 1
(
AGGF1
) is a novel identified initiator of angiogenesis through promoting the proliferation of endothelial cells. The continuous angiogenesis plays a key role in the growth, invasion, and metastasis of
hepatocellular carcinoma
(
HCC
), while the diagnostic and prognostic roles of
AGGF1
for
HCC
need to be further studied. MATERIAL AND METHODS The mRNA sequencing datasets and clinical features of
HCC
patients were extracted from The Cancer Genome Atlas database. The relationship between clinical features and
AGGF1
expression was analyzed by Wilcoxon test. Further validation explorations were carried out using online database Oncomine. The diagnostic receiver operating characteristic curves of
AGGF1
and alpha-fetoprotein were compared to examine the diagnostic efficacy of
AGGF1
. Survival analysis and Gene Set Enrichment Analysis were performed to explore the prediction value and potential mechanism of
AGGF1
dysregulation in
HCC
. RESULTS Comprehensive overexpression of
AGGF1
was observed in
HCC
, correlating with poor overall survival. Upregulated level of
AGGF1
was statistically associated with poor differentiated histological grade, advanced cancer stage and T classification.
AGGF1
was a more effective diagnostic marker than alpha-fetoprotein in
HCC
. Several important pathways related to
HCC
including pathway in cancer and P53 signaling pathway were differentially enriched in the high
AGGF1
expression phenotype. CONCLUSIONS
AGGF1
was a potential diagnostic and prognostic marker for poor clinical outcomes in
HCC
patients. Moreover, vital pathways regulated by
AGGF1
in
HCC
may include regulation of autophagy, Wnt signaling pathway, pathway in cancer, cell cycle, and P53 signaling pathway.
...
PMID:Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis. 3209 Sep 83
