Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
Natural killer cell receptor
group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of
NKG2D
gene.
Methods:
We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of
hepatocellular carcinoma
(
HCC
) patients, chronic hepatitis B patients and healthy controls by methylation-specific PCR and the mRNA expression level was examined by real-time quantitative PCR.
Results:
The methylation frequency of NKG2D promoter in
HCC
patients was higher than that of chronic hepatitis B patients and healthy controls. NKG2D promoter methylation has a good predictive value for
HCC
diagnosis.
Conclusion:
NKG2D promoter methylation can be used as a noninvasive marker for detecting
HCC
.
...
PMID:Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma. 3141 Oct 40
