Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
MicroRNAs (miRNAs) are short, non-coding RNAs with post-transcriptional regulatory function, playing crucial roles in cancer development and progression of
hepatocellular carcinoma
(
HCC
). Previous studies have indicated that miR-1180 was implicated in diverse biological processes. However, the underlying mechanism of miR-1180 in
HCC
has not been intensively investigated. In this study, we aimed to investigate the role of miR-1180 and its target genes in
HCC
. We found that miR-1180 expression was significantly increased in
HCC
cells and clinical tissues compared with their corresponding controls. Overexpression of miR-1180 promoted cell proliferation in
HCC
cell line HepG2.
TNFAIP3 interacting protein 2
(
TNIP2
), a potential target gene of miR-1180, and were validated by a luciferase assay. Further studies revealed that miR-1180 regulated cell proliferation of
HCC
by directly suppressing
TNIP2
expression and the knockdown of
TNIP2
expression reversed the effect of miR-1180-in on
HCC
cell proliferation. In summary, our data indicated that miR-1180 might act as a tumor promoter by targeting
TNIP2
during development of
HCC
.
...
PMID:MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression. 2704 43
