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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors investigated the magnetic resonance appearance of hepatocellular carcinoma using a 1.5-Tesla magnet. Twenty-four patients with pathologically proven hepatocellular carcinoma had magnetic resonance imaging (MRI) studies, which were retrospectively reviewed. All patients were imaged with at least two of the following techniques: (1) T1-weighted (T1W), (2) T1-weighted with Gd-DTPA enhancement (T1W-E), (3) T2-weighted (T2W), (4) proton density (PD), and (5) gradient-recalled echoes (GRE). T1W images were equal to T2W images for tumor detection using a grading system. T1W images were slightly better than T2W images for the total number of lesions detected. The other pulsing techniques (PD, T1W-E, and GRE) detected fewer lesions. Eight cases of hepatocellular carcinoma (33%) had nonhomogeneous increased signal intensity on both T1W and T2W images. The authors conclude that T1W images are equal to T2W images for detection of hepatocellular carcinoma. The authors also conclude that 33% of hepatocellular carcinomas have an imaging pattern with increased signal intensity on both T1W and T2W images. This pattern is atypical for most other hepatic masses and hence can be used to suggest the mass is hepatocellular carcinoma.
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PMID:MR imaging of hepatocellular carcinoma at 1.5 Tesla. 131 48

Thirty-eight patients with focal liver tumors (20 hepatomas, 18 hemangiomas) were studied by dynamic sequential inversion recovery (IR) snapshot fast low angle shot (FLASH) MR imaging with Gd-DTPA. Immediately after 0.05 mmol/kg Gd-DTPA was administered intravenously for 2-3 s followed by flushing with normal saline for 4-5 s, 10 images were obtained in the first 20 s (time zero is the end of flush, early phase). Then, one image every 30 s from 1 to 3 min (late phase) and images at 5 min and 7 min (delayed phase) were obtained serially. Hepatomas showed total enhancement in 18 of 20 patients in the early phase, and isointense or low intensity enhancement with respect to the surrounding liver parenchyma in 18 patients in the late to delayed phases. Hemangiomas showed peripheral enhancement in 14 patients in the early phase, but did not show total enhancement (except for two hemangiomas less than 3 cm in size) in the early phase, and showed high intensity enhancement in 15 patients in the late phase. Ninety percent of hepatomas and 82% of hemangiomas showed their characteristic enhancement patterns in the early to delayed phases. We conclude that dynamic sequential IR snapshot FLASH MR images enhanced with Gd-DTPA can facilitate differentiation between hepatomas and hemangiomas.
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PMID:Differentiation between hepatoma and hemangioma with inversion-recovery snapshot FLASH MRI and Gd-DTPA. 131 97

Most of the primary hepatocellular carcinoma and hemangioma in TIWI are having low signals. Hemangioma is relatively lower in signal intensity than primary hepatocellular carcinoma, but they are really no so easy compare by bare eye. On the contrary, in T2WI, hemangioma is more brighter than primary hepatocellular carcinoma. So, by compare the variety shows from T1WI to T2WI, we can differentiated between primary hepatocellular carcinoma and hemangioma. By measuring the signal intensity in non-tumor area, there are no marked different in T1WI and T2WI, but hemangioma, as compare with primary hepatocellular carcinoma in signal intensity, is lower in T1WI and much higher in T2WI. Such results are all having statistic significant with p value less than 0.05. In measuring the different in signal intensity or ratio between tumor and non-tumor areas, there were mark different in T2WI and whereas there were no different in T1WI. By using two-point method, the T2-relaxation is measured in twenty eight cases of primary hepatocellular carcinoma and thirteen cases (twenty four lesions) of hemangioma. We found that there were nearly equal in nontumor areas, but there were mark different in T2-relaxation. In comparison with intravenous injection of Gd-DTPA in 10 cases of primary hepatocellular carcinoma and six cases of hemangioma, the latter were having similar dynamic CT appearance. Enhancement of signal intensity was found starting from peripheral part to central area. The primary hepatocellular carcinoma were having none of the above phenomenon. The liver MRI study is still expensive and time consuming.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Differentiation between primary hepatocellular carcinoma and hemangioma on MRI]. 131 3

The breath-hold multislice dynamic study (BMDS) in MRI, which can scan the entire liver during a single breath-holding, was applied to 16 patients with 30 focal lesions of hepatocellular carcinoma (HCC). The BMDS was performed at 20 seconds and 3 minutes after the bolus injection of Gd-DTPA, by gradient echo pulse sequence (FLASH). 29 nodules were detected in the BMDS, showing rapid enhancement on early phase and decline on delayed phase images. The BMDS was more sensitive than conventional MR images. Therefore, the BMDS seems to be useful for the diagnosis of HCC with multiple as well as solitary nodules.
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PMID:[Evaluation of breath-hold multislice dynamic MRI of hepatocellular carcinomas]. 131 53

Thirty-five patients with hepatic hemangioma (n = 12), metastasis (n = 10), hepatocellular carcinoma (HCC) (n = 10) and focal nodular hyperplasia (n = 3) were examined with the fast low-angle shot (FLASH) technique and an intravenous bolus injection of Gd-DTPA. In order to differentiate the lesions, the following criteria were used: a) pre Gd-DTPA intensity of lesions; b) post Gd-DTPA patterns of contrast enhancement. On the basis of these criteria, an unquestionable differential diagnosis could be made. Hemangiomas were characterized by an hypointense mass before Gd-DTPA, by peripheral contrast enhancement and by subsequent continuous hyperintense fill-in; thus, hemangiomas were visualized as hyperintense lesion during the late phase. Before contrast administration hypovascular metastases appeared as hypointense; they were characterized by delayed uptake of contrast agent. HCCs were hyperintense lesions before contrast administrations; then, quick contrast enhancement and rapid decrease in signal intensity were observed with visualization of a hyperintense ring due to the capsule. Finally, focal nodular hyperplasia appeared isointense or hypointense relative to normal liver on precontrast scans; the lesions were enhanced transiently with subsequent quick dismission of contrast agent. This initial experience suggests dynamic contrast-enhanced MR imaging as an effective method to improve the differential diagnosis among hepatic tumors when precontrast T2-weighted images are equivocal.
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PMID:[The dynamic magnetic resonance study of focal liver lesions by FLASH sequences with bolus intravenous gadolinium-DTPA]. 131 58

Several parameters calculated with a new functional imaging agent for the liver, Tc-99m DTPA-galactosyl human serum albumin, were evaluated in 9 patients with liver cirrhosis, one with hepatocellular carcinoma, and five with both liver cirrhosis and hepatocellular carcinoma. LU3, which represents the cumulative uptake of the tracer from 3 to 4 minutes after injection, showed a strong correlation (r = 0.858, p = 0.0001) with LHL15, which represents the count ratio for the liver to sum for the liver and heart 15 minutes after injection of the tracer. It also showed a strong correlation (r = -0.896, p = 0.0001) with the indocyanine green retention rate (ICGR15). Regional ICGR15 is therefore calculable from the regional LU3. GSAR15, which represents the radioactivity of the tracer retained in the blood 15 minutes after injection, showed a strong correlation (r = 0.878, p = 0.0001) with HH15, which represents the count ratio for the heart 15 minutes after injection of the tracer divided by the count for the heart 3 minutes after injection. In conclusion, LU3 and GSAR15 are interesting and promising parameters for assessing liver function.
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PMID:A new liver functional study using Tc-99m DTPA-galactosyl human serum albumin: evaluation of the validity of several functional parameters. 132 Mar 89

We acquired dynamic images over the whole liver by inversion recovery snap shot FLASH method after a bolus intravenous injection of Gadolinium-DTPA. Each nodule of hepatoma in the liver showed early enhancement and gradually turned to show low intensity. In two cases of hepatoma, small intrahepatic metastases, which were not detected by US, CT and spin-echo image of MRI, were suspected as high intensity nodules on early phase. Also recurrent areas after TAE were enhanced on early phase. This method is practical for improving the detection of lesions and is useful for evaluating the recurrence after TAE.
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PMID:[Evaluation of multislice dynamic MR imaging of the whole liver by inversion recovery snap shot FLASH method]. 132 68

Dynamic 3 dimensional Fourier transformation (3DFT) FISP MR imaging was performed in 5 patients with hepatocellular carcinoma before partial hepatectomy. Immediately after 0.1 mmol/kg of Gd-DTPA was administered intravenously, 3DFT FISP images (TR/TE/flip angle/slice thickness, 20 msec/8 msec/30 degrees/2-4 mm) were obtained every 30 seconds until 150 sec. We correlated dynamic MR images of the 5 patients with gross and microscopic findings. Some regions in the tumor corresponding to viable cells showed high intensity enhancement and other regions corresponding to necrotic regions showed no enhancement on the early phase images. We concluded that dynamic 3DFT FISP MR imaging which had good spatial resolution was useful in evaluating the vascularity of the tumor.
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PMID:[Dynamic 3DFT FISP MR imaging of hepatocellular carcinoma]. 132 70

Gd-DTPA enhanced dynamic MR studies were evaluated in six patients with hepatocellular carcinoma associated with portal vein tumor thrombus. The portal vein tumor thrombus was clearly visualized as a low intensity lesion. The hepatic segment supplied by the portal vein showed high intensity, probably due to decreased portal blood flow and compensatory arterial blood flow. Tumors located in this segment were shown as areas of relatively low intensity compared with segmental high intensity areas. Thus dynamic MR study was found to be a useful method for differentiating the tumor from the surrounding nontumorous tissue with decreased portal blood flow.
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PMID:Dynamic MR studies of hepatocellular carcinoma with portal vein tumor thrombosis. 133 18

Dynamic MRI with injection of Gd-DTPA was performed in 7 patients with hepatocellular carcinoma associated with portal vein tumor thrombus. A portal vein tumor thrombus was clearly visualized as a low intense structure. The segment supplied with this portal vein shows high intensity, probably due to the decrease in portal blood flow and compensated arterial blood flow. A tumor itself, located in this segment, was shown as a low intense area. Thus dynamic MRI is a useful method for differentiating the tumor from the surrounding nontumorous tissue with decrease in portal flow.
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PMID:[Dynamic MRI of hepatocellular carcinoma with portal vein tumor thrombus]. 185 85


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