Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Liver damage involves oxidative stress and a progression from chronic hepatitis to
hepatocellular carcinoma
(
HCC
). The increased incidence of liver disease in Egypt and other countries in the last decade, coupled with poor prognosis, justify the critical need to introduce alternative chemopreventive agents that may protect against liver damage. The aim of this study was to evaluate the efficacy of exopolysaccharide-peptide (PSP) complex extracted from
Pleurotus ostreatus
as a hepatoprotective agent against diethylnitrosamine (DEN)/carbon tetrachloride (CCL
4
)-induced hepatocellular damage in rats. The levels of liver injury markers (ALT, AST and
ALP
) were substantially increased following DEN/CCl
4
treatment. DEN/CCl
4
- induced oxidative stress was confirmed by elevated levels of lipid peroxidation and decreased levels of superoxide dismutase, glutathione-S-transferase, and reduced glutathione. PSP reversed these alterations in the liver and serum, and provided protection evidenced by reversal of histopathological changes in the liver. The present study demonstrated that PSP extract from
P. ostreatus
exhibited hepatoprotective and antioxidant effects against DEN/CCl
4
-induced hepatocellular damage in rats. Given the high prevalence of HCV-related liver damage in Egypt, our results suggest further clinical evaluation of
P. ostreatus
extracts and their potential hepatoprotective effects in patients with liver disease.
...
PMID:Exopolysaccharide-peptide complex from oyster mushroom (
Pleurotus ostreatus
) protects against hepatotoxicity in rats. 3324 Nov 28
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