Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ability of liver lipid-exchange proteins to introduce foreign phospholipids into microsomes was used in a study of the lipid dependence of glucose-6-phosphatase. Supplementation of intact rat liver and hepatoma microsomes with exogeneous aminophospholipids prevents the decline of glucose-6-phosphatase activity during incubation, whereas the introduction of exogeneous phosphatidylcholine has no protective effect. On the contrary with deoxycholate-disrupted hepatoma microsomes, introduction of additional phosphatidylcholine causes activation while phosphatidylethanolamine has only little effect. The results are explained by assuming that the transport unit and the catalytic moiety of the glucose-6-phosphatase system have different lipid requirements, the activity of the former protein depending mainly on phosphatidylethanolamine and phosphatidylserine and that of the catalytic protein depending on phosphatidylcholine. In deoxycholate-disrupted liver microsomes (in which both the glucose-6-phosphatase activity and the phosphatidylcholine content are much higher than in hepatoma microsomes) incubation with phosphatidylcholine and lipid-exchange proteins alters neither the phospholipid composition nor the enzyme activity. THis suggests that the diminished activity of glucose-6-phosphatase in hepatomas may be partly due to a low level of phosphatidylcholine.
Eur J Biochem 1979 Sep
PMID:Use of protein-mediated lipid exchange in the study of membrane-bound enzymes. The lipid dependence of glucose-6-phosphatase. 22 88

The value of the leucocyte adherence inhibition (LAI) test in the diagnosis of hepatocellular carcinoma (HCG) was investigated in 36 patients with this tumour. The sensitivity and specificity of the tube LAI test was assessed in 21 patients with HCC, 15 apparently healthy individuals, 9 patients with various forms of benign liver disease and 5 patients with non-hepatic neoplasms. In only 42% of the HCC patients tested was leucocyte adherence to glass reduced to a greater extent than in the healthy controls and in the patients with non-hepatic neoplasms, and the differences were not statistically significant. Moreover, positive results were obtained in 6/9 patients with benign hepatic disease. A further 15 patients were tested against extracts of HCC tissue using the haemacytometer LAI method. Of these, 53% gave positive results. In all, only 17/36 patients (47%) gave positive LAI responses. The test is thus of limited value in the diagnosis of HCC. The high false-negative result rate may be due either to abrogation of the immune response in HCC patients with large tumour burdens or to antigenic heterogeneity in HCC.
Br J Cancer 1979 Sep
PMID:Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma. 22 91

Uridine kinase activities were found chiefly in the soluble fractions of rat tissues. In normal adults the activities ranged from 13 munits/g in skeletal muscle to 178 munits/g in colon. Enzyme activities in several rat neoplasms were significantly higher (e.g. in a fibrosarcoma, mammary carcinoma, renal carcinoma, pancreatic carcinoma and lymphocytic lymphoma, but not in a fast-growing Morris hepatoma). The activities were not related to tumour growth rates or sizes. In normal foetal liver, lung, brain, heart and kidney, uridine kinase concentrations equalled or exceeded those in the adult homologous tissue, but maximal activities in liver were reached 3--5 days post partum. In suckling rats the intestinal activity decreased substantially immediately after birth and normally did not rise again until late in the third postnatal week. Premature upsurges could be evoked by an injection of cortisol or by starvation of the pups overnight. Pancreatic activity was absent from 1-day-old rats, and only about 5% of the adult activity was reached by day 20; adult activities were attained rapidly after weaning. In pancreas, precocious formation or uridine kinase was elicited by overnight starvation of 2-week-old rats.
Biochem J 1979 Sep 15
PMID:Uridine kinase activities in developing, adult and neoplastic rat tissues. 22 27

An hypothesis is presented which states that the endocrine systems for the synthesis of sex hormones as we know it presently might be a specialization of a system operating at the cellular level in multicellular organisms. If this were true, then a possible role of estrogens in the carcinogenesis of nontarget tissues may be postulated. Evidence for this hypothesis is highly theoretical, but is based on extrapolations from existing experimental data. The mitogenic effect of the estrogen-receptor complex is thought to be similar in both normal and malignant target tissues. Since receptors are present in several types of nontarget tissues, especially in the case of lesions at the nuclear acceptor sites, the complex might be able to cause successive mitoses in these regions, hence carcinogenesis. Several experimental approaches to test this hypothesis are presented as suggestions; these include using malignant tissues which are most likely to divide through the action of their own estrogen, such as feminizing hepatoma, and studying the mitogenic effect of locally formed estrogens through experimentation with the anti-estrogen CI-628.
Med Hypotheses 1979 Sep
PMID:A possible role of estrogens in carcinogenesis of non-target tissues. 23 Apr 10

When soluble hepatocellular carcinoma (HCC) extract prepared by 3 M KCl solution was passed through a column of Sephadex G-200, four fractions (designated as I, II, III, IV) could be obtained from the elution profile. By leukocyte migration inhibition assay, the active component of soluble HCC extract which represented tumor-associated antigen was shown to be contained in fractions I and II.
Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi 1979 Sep
PMID:Purification of soluble hepatocellular carcinoma extracts. 23 74

The N-[p-(fluorosulfonyl)benzyl] derivatives of L-asparagine and L-glutamine (1a,b) were synthesized as potential inhibitors of L-asparagine synthetase (ASase). Condensation of p-(fluorosulfonyl)benzylamine (2) with the suitably protected amino acid in the presence of dicyclohexylcarbodiimide, followed by deblocking, afforded 1a and 1b. Derivatives 1a and 1b at 10 mM inhibit ASase isolated from Novikoff hepatoma (rats) by 60 and 46%, respectively. Preliminary results on inhibition of Jensen sarcoma (L-asparaginase sensitive) and JA-1 sarcoma (L-asparaginase resistant) tissue cultures by 0.3 mM 1a (139,90%) and 1b (101, 103%), respectively, are discussed.
J Med Chem 1975 Sep
PMID:Potential inhibitors of L-asparagine biosynthesis. 3. Aromatic sulfonyl fluoride analogs of L-asparagine and L-glutamine. 24 24

After a suspension of tumor pieces was grafted into newborn and adult (CBA X C57BL/6J)F1 and BALB/c mice, the growth of Lewis lung adenocarcinoma and mammary gland adenocarcinoma was inhibited in newborn mice, whereas sarcoma of the rectum (SR-1-75) grew at the same rate in newborn and adult recipients. Neonatal thymectomy stimulated the growth of hepatoma (H-2-73) in newborns. The degree of tumor growth inhibition was age-dependent: The maximum inhibition was observed in 1- to 6-day-old recipients, but later it gradually decreased. The hepatoma (H-2-73) and ovarian carcinoma (OC-1-75) with inhibited growth in newborns and the tumor (SR-1-75) with uninhibited growth had equally low immunogenicity. The data suggested that newborns possess factors that inhibit tumor growth but these factors disappear with increased age of recipients.
J Natl Cancer Inst 1978 Sep
PMID:Nonimmune and immune surveillance. II. Effect of recipient's age, tumor immunogenicity, and neonatal thymectomy on tumor growth inhibition. 27 51

Thirty C3H-AvyfB male mice from 3 to 15 months of age were killed, and the genesis of their hepatocellular neoplasms was studied. As the mice aged, the number of tumors per liver and mean diameter of the tumors increased. Histologically, the smallest tumors were composed of solid sheets of cells and were better differentiated than the largest tumors. Small foci of hepatocytes in prominent trabeculae formation was a common characteristic of large tumors. In addition, 18 metastatic hepatocellular carcinomas observed in aged C3H-AvyfB, C3HfC, C3H, C3HfB, (C3HfB x YBR)F1, or C57BL/6 mice were also included for a morphologic study of their primary and metastatic lesions. Invariably, the pulmonary metastases were composed of a well-differentiated sheet of hepatocytes that resembled those in the solid liver tumors. The smallest hepatocellular neoplasms appear to represent early stages in the development of metastatic hepatocellular carcinoma.
J Natl Cancer Inst 1978 Sep
PMID:Evaluation of hepatocellular neoplasms in mice. 27 58

The effects of a choline-devoid (CD) or a choline-supplemented (CS) diet on the induction of liver tumors in rats by DL-ethionine were investigated. Groups of male outbred Sprague-Dawley rats were fed a plain CD or a plain CS diet, or the same diets containing 0.05% DL-ethionine. Hepatocellular carcinomas developed in 50% of the rats fed the CD+ethionine diet for 14 weeks and in about 80% of the rats fed the same diet for 22-30 weeks. No hepatocellular carcinomas developed in rats fed the CS+ethionine diet, the plain CD diet, or the plain CS diet up to 30 weeks. The findings suggest that a CD diet alters the response of rat liver to DL-ethionine and leads to an early and enhanced induction of hepatocellular carcinoma.
J Natl Cancer Inst 1978 Sep
PMID:Enhancement of DL-ethionine-induced liver carcinogenesis in rats fed a choline-devoid diet. 27 59

The role of adhesive fraction of T lymphocytes in nonreactivity of mice to hepatoma 22a was studied. It was shown that the removal of the adhesive fraction from the spleen suspension enriched with T lymphocytes promotes intensification of cell immunity in tumor-tolerant mice.
Biull Eksp Biol Med 1979 Sep
PMID:[Role of adhesive lymphoid cell subpopulation in areactivity to hepatoma 22a]. 31 42


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