Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019204 (
hepatocellular carcinoma
)
71,386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lewis antigens related to the ABO blood group are fucosylated oligosaccharides and are synthesized by specific glycosyltransferases (FUTs). FUTs are involved in various biological processes including cell adhesion and tumor progression. The fucosyltransferase-2 gene (
FUT2
) encodes
alpha (1,2) fucosyltransferase
, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans. Aberrant fucosylation occurs frequently during the development and progression of
hepatocellular carcinoma
(
HCC
). However, the association of
FUT2
polymorphisms with
HCC
development has not been studied. Therefore, we aimed to investigate the association of
FUT2
polymorphisms with demographic, etiological, and clinical characteristics and with susceptibility to
HCC
. In this study, a total of 339 patients and 720 controls were recruited. The genotypes of
FUT2
at four single-nucleotide polymorphisms (SNPs; rs281377, rs1047781, rs601338, and rs602662) were detected by real-time polymerase chain reaction from these samples. Compared with the wild-type genotype at SNP rs1047781, which is homozygous for nucleotides AA, at least one polymorphic T allele (AT or TT) displayed significant association with clinical stage (
p
= 0.048) and tumor size (
p
= 0.022). Our study strongly implicates the polymorphic locus rs1047781 of
FUT2
as being associated with
HCC
development.
...
PMID:
FUT2
genetic variants as predictors of tumor development with hepatocellular carcinoma. 2882 26
