Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019204 (hepatocellular carcinoma)
 71,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of acute emphysematous cholecystitis that occurred following hepatic artery embolization for hepatocellular carcinoma but was cured by conservative therapy. In view of its pathogenesis, emphysematous cholecystitis seems likely to be a complication of hepatic artery embolization.
Cardiovasc Intervent Radiol 1986
PMID:Emphysematous cholecystitis: complication of hepatic artery embolization. 301 9

Transcatheter arterial embolization was performed on a patient with hepatoma complicated by obstructive jaundice after the patient's condition had been improved by percutaneous biliary drainage. As a result of the embolization, a reduction in size was observed in both the main tumor and the tumor that had invaded the common bile duct. Even after removing the biliary drainage tube, there was no recurrence of obstructive jaundice for 6 months.
Cardiovasc Intervent Radiol 1987
PMID:Transcatheter arterial embolization in hepatoma complicated with obstructive jaundice. 302 32

Twelve cases of hepatocellular carcinoma treated by arterial embolization were followed with ultrasonography. Shrinkage of the tumor after the therapy was confirmed in all cases. Echo level reduction in the tumor occurred in 10 cases. High-level reverberation echoes with acoustic shadows emerged in seven cases; however, these echoes were not detected in any cases 3 weeks after the procedure. Echoes were considered either as the consequence of gas produced in the tumor or air trapped in the embolic substance. Ultrasonography, therefore, is an effective technique for the posttherapeutic evaluation of arterial embolization therapy for hepatocellular carcinoma.
Cardiovasc Intervent Radiol 1983
PMID:Evaluation by ultrasonography of arterial embolization therapy for hepatocellular carcinoma. 630 91

A dilated hepatic falciform artery (HFA) arising from the left hepatic artery was demonstrated on arteriography prior to chemoembolization of an unresectable hepatocellular carcinoma (HCC) located predominantly in the left lobe of the liver. The HFA was occluded by microcoils to prevent a possible toxic supraumbilical skin rash following chemoembolization of the HCC via the left hepatic artery. There were no postprocedure complications. We consider this procedure useful for improving the safety of chemoembolization.
Cardiovasc Intervent Radiol
PMID:Embolization of the hepatic falciform artery to prevent supraumbilical skin rash during transcatheter arterial chemoembolization for hepatocellular carcinoma. 764 96

We examined four commercially available human cell lines for endothelin-converting-enzyme-(ECE) like activity and compared the results with primary porcine aortic endothelial cell enzymes. The cells that were investigated were 293 (transformed primary human embryonal kidney), Hep G2 (human hepatocellular carcinoma), HUVECs (human umbilical vein endothelial cells), and U937 (human histiocytic lymphoma). The relative ECE-like activities were determined in cytosolic and particulate extracts of each cell type. Enzyme activity against pro-ET-1 was measured at pH 4 and 7, using a C-terminal Trp-specific antibody to ET-1 radioimmunoassay and by high-performance liquid chromatography analysis of the enzyme hydrolysis products of pro-ET-1. Inhibition by EDTA at pH 7 or pepstatin at pH 4 was used to classify the pro-ET-1 processing enzymes from the human cell lines as either metallo- or aspartylproteinases. The particulate extract of the primary porcine aortic endothelial cells contained both aspartyl and metallo ECE-like enzymes. No ECE-like activity was present in either the cytosolic or particulate extracts of the U937 nor 293 cells. Neither the particulate extract of the Hep G2 cells nor the cytosolic extract of the HUVECs had any ECE-like activity. The cytosolic extract of the Hep G2 cells and the particulate extract of the HUVECs had an ECE-like activity at pH 7 that was inhibited by 10 mM EDTA, qualifying these enzymes as members of the metalloproteinase family.
J Cardiovasc Pharmacol 1993
PMID:A comparison of endothelin-converting enzyme activity from primary porcine aortic endothelial cells with activities in cultured human cell lines. 812 Nov 80

Management of 26 arterioportal fistulae (APFs) is reported. Among 13 hepatoma-induced fistulae (group A), conservative treatment was ineffective in 8 patients, and arterial embolization alleviated portal hypertension in the other 5. Of 10 iatrogenic APFs (group B), the 3 largest were successfully embolized, the remaining lesions resolved spontaneously. Three spontaneous nonmalignant APFs (group C) were embolized. Excellent results were obtained in 2 patients, and the other died of severe postembolization hepatic failure. Because long-standing APFs may cause severe portal hypertension with consequent variceal bleeding they should be treated. Arterial embolization is indicated in most patients.
Cardiovasc Intervent Radiol
PMID:Intrahepatic arterioportal fistulae: role of transcatheter embolization. 813 Nov 68

A patient with hepatocellular carcinoma, associated segmental portal vein thrombosis, and accompanying pneumobilia, developed a liver abscess and sepsis following transcatheter chemoembolization (TCE). It was believed that the combination of bile duct necrosis after arterial occlusion and pneumobilia led to ascending enteric infection and seeding of the necrotic tumor, which ultimately led to fatal outcome. We conclude that TCE is contraindicated in such cases.
Cardiovasc Intervent Radiol
PMID:Fatal septic complication of transcatheter chemoembolization for hepatocellular carcinoma. 826 33

A retrospective analysis was made of the effect of transcatheter arterial chemoembolization (TACE) in 87 patients with recurrent hepatocellular carcinoma (HCC). In contrast to the predominantly single nodular HCC (60.2%) on preoperative angiography, recurrent HCC showed a multinodular pattern in 54.2%. Preoperative TACE had significantly prolonged the interval between surgery and recurrence. One- and 2-year survival rates after TACE of the 87 recurrent HCCs were 74.7% and 55.%, respectively, which were not significantly different from those of a control group of 206 patients with HCC in Child's class A, who were treated with TACE only. We believe that TACE is an effective measure in the management of preoperative and recurrent HCC.
Cardiovasc Intervent Radiol
PMID:Postoperative recurrence of hepatocellular carcinoma: results of transcatheter arterial chemoembolization. 838 9

Transcatheter chemoembolization using Lipiodol (Lp) mixed with chemotherapeutic agents followed by Gelfoam particle injection only to the tumor-bearing hepatic segment (segmental Lp transcatheter hepatic artery embolization) (TAE) was applied to more than 100 patients with hepatocellular carcinoma and metastatic liver cancer. For segmental Lp-TAE, knowledge of the variations of intrahepatic arterial anatomy is important. Furthermore, the catheters and guidewires, volume of Lp, kinds and dose of chemotherapy, preparation of the mixture of Lp and chemotherapy (Lp-emulsion), method of injection of Lp-emulsion and Gelfoam particles, as well as the follow-up computed tomography examination are key items to the success of the procedure and are reviewed.
Cardiovasc Intervent Radiol
PMID:Segmental embolotherapy for hepatic cancer: keys to success. 838 93

This retrospective study examined the computed tomography (CT) criteria for judging the effectiveness of transcatheter arterial Lipiodol-chemoembolization (Lp-chemo-TAE) in 35 cases with hepatocellular carcinoma (HCC). Massive necrosis, defined as involving 97% or more of the HCC nodule, was observed in 15 cases after Lp-chemo-TAE, whereas nonmassive necrosis, defined as involving < or = 96% of the HCC nodule, was observed in the remaining 20 cases. In 12 of 15 cases (80%) with massive necrosis, uniform dense retention of Lipiodol (Lp) was observed throughout the HCC nodule on CT images 3-4 weeks after Lp-chemo-TAE as opposed to only one (5%) of 20 cases with nonmassive necrosis (p < 0.01). Eight of nine cases (89%) with massive necrosis had tumor attenuation values of 365 Hounsfield units (HU) or greater on CT images 3-4 weeks after embolization, as opposed to only four (27%) of 15 cases with nonmassive necrosis (p < 0.01). We conclude that the effectiveness of the Lp-chemo-TAE can be judged on CT from the degree and duration of Lp retention in the HCC nodule and the measurement of the attenuation value of the HCC nodule.
Cardiovasc Intervent Radiol
PMID:Lipiodol retention and massive necrosis after lipiodol-chemoembolization of hepatocellular carcinoma: correlation between computed tomography and histopathology. 840 81


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